Synthesis and Application of Robust Spiro [Fluorene-9] CAAC Ruthenium Alkylidene Complexes for the "One-Pot" Conversion of Allyl Acetate to Butane-1,4-diol.

A series of a novel CAAC ligands featuring a spiro-fluorene group have been synthesized and complexed with ruthenium alkylidenes, yielding the corresponding Hoveyda-type derivatives as a new family of olefin metathesis catalysts. The novel complexes have been characterized by XRD, HRMS and NMR measurements. The synthetised complexes were tested in catalysis and showed good activity in olefin metathesis, as demonstrated on diethyl diallylmalonate and allyl acetate substrates.

"Inverted" Cyclic(Alkyl)(Amino)Carbene (CAAC) Ruthenium Complex Catalyzed Isomerization Metathesis (ISOMET) of Long Chain Olefins to Propylene at Low Ethylene Pressure.

Isomerization Metathesis (ISOMET) reaction is an emerging tool for "open loop" chemical recycling of polyethylene to propylene. Novel, latent N-Alkyl substituted Cyclic(Alkyl)(Amino)Carbene (CAAC)-ruthenium catalysts (5a-Ru, 3b-Ru - 6c-Ru) are developed rendering "inverted" chemical structure while showing enhanced ISOMET activity in combination with (RuHCl)(CO)(PPh) (RuH) double bond isomerization co-catalyst. Systematic investigations reveal that the steric hindrance of the substituents on nitrogen and carbon atom adjacent to carbene moiety in the CAAC ligand have significantly improved the catalytic activity and robustness.

The Importance of Nutrition in Menopause and Perimenopause-A Review.

Menopause is associated with an increased prevalence of obesity, metabolic syndrome, cardiovascular diseases, and osteoporosis. These diseases and unfavorable laboratory values, which are characteristic of this period in women, can be significantly improved by eliminating and reducing dietary risk factors. Changing dietary habits during perimenopause is most effectively achieved through nutrition counseling and intervention.

Pharmacotherapeutic Potential of against Colorectal Cancer Growth and Proliferation.

species are widespread and diverse in African ecosystems, and this commonly correlates to their habitual use as reservoirs of herbal medicine. The side effects associated with chemotherapy and the development of antimicrobial resistance to empirically used antimicrobial drugs are substantial, paving the way for novel phytotherapeutic approaches. This comprehensive study aimed to evaluate and present as a compelling alternative with potential benefits in colorectal cancer (CRC) treatment.

Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the effect of oral tyrosine kinase inhibitors.

Tyrosine kinases are crucial signaling components of diverse biological processes and are major therapeutic targets in various malignancies and immune-mediated disorders. A critical step of development of novel tyrosine kinase inhibitors is the transition from the confirmation of the effects of drug candidates to the analysis of their efficacy. To facilitate this transition, we have developed a rapid assay for the analysis of the effect of oral tyrosine kinase inhibitors on basal tyrosine phosphorylation of circulating mouse neutrophils.

Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets-A Narrative Review.

Plant-based diets are becoming more popular for many reasons, and epidemiological as well as clinical data also suggest that a well-balanced vegan diet can be adopted for the prevention, and in some cases, in the treatment of many diseases. In this narrative review, we provide an overview of the relationships between these diets and various conditions and their potential biochemical background. As whole plant foods are very rich in food-derived antioxidants and other phytochemicals, they have many positive physiological effects on different aspects of health.

Terahertz pulses induce segment renewal via cell proliferation and differentiation overriding the endogenous regeneration program of the earthworm .

Terahertz (THz) irradiation of excised earthworms is shown to cause overriding of the genetically determined, endogenously mediated segment renewing capacity of the model animal. Single-cycle THz pulses of 5 µJ energy, 0.30 THz mean frequency, 293 kV/cm peak electric field, and 1 kHz repetition rate stimulated the cell proliferation (indicated by the high number of mitotic cells) and both histogenesis and organogenesis, producing a significantly higher number of regenerated segments.

Selective Synthesis of -Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation.

The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.

[Plant-based diets: a review].

Plant-based diet is an old-new trend in nutrition. In this review based on a historical context, we wish to introduce this popular nutritional trend. Our aim is to present plant-based diet as a primary measure for prevention.

The potential application of red mud and soil mixture as additive to the surface layer of a landfill cover system.

Red mud, the by-product of aluminum production, has been regarded as a problematic residue all over the world. Its storage involves risks as evidenced by the Ajka red mud spill, an accident in Hungary where the slurry broke free, flooding the surrounding areas. As an immediate remediation measure more than 5cm thick red mud layer was removed from the flooded soil surface.

Characterization of thermal properties of municipal solid waste landfills.

Municipal waste landfills represent not only a source of landfill gases, but a source of thermal energy as well. The heat in landfills is generated by physical, chemical and microbiological processes. The goal of our study was to characterize the thermal properties of municipal solid waste (MSW) samples of the given landfill.

Aromatic sulfonamides containing a condensed piperidine moiety as potential oxidative stress-inducing anticancer agents.

A 30-membered piperidine ring-fused aromatic sulfonamide library was synthetized, including N-arylsulfonyl 1,2,3,4-tetrahydroquinolines, 1,2,3,4-tetrahydroisoquinolines and 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indoles. The compounds induced oxidative stress and glutathione depletion in HT168 melanoma and K562 leukemia cells and in micromolar concentrations exerted cytotoxic effects. Among the tested sulfonamides, compounds 21, 22, 23, 35 and 41 exhibited 100% cytotoxic effects with low (< 10 µM) EC50 values on K562 cells.

[Puer aeternus].

The social changes of the last few decades have resulted in the revaluation of the classic life-stage models. The time of finding active employment and establishing a family have been postponed, thus not supporting self reliance and undertaking adult roles. In our comprehensive study we discuss the social and demographic phenomena that have contributed to the formation of post-adolescence.

Practical aspects of identifying and correcting worksite stress in post-infarction patients returning to work.

The authors propose a dynamic 'man-work system' model, centered around the bodily strain, which is determined jointly by the momentary efficiency of the organism and the sum of stresses acting at a given point of time, i.e. integrated along various durations.

Shoulder strain in keyboard workers and its alleviation by arm supports.

Keyboard work consists mostly of dynamic contractions of the small muscles of the forearms and hands. This is accompanied by continuous activity in the arm, shoulder and neck muscles keeping the head and hand in the correct position. Eliminating the weight from the arm by means of support and the position of the arms influences the electrical activity of shoulder muscles when working at a keyboard.

Organization of blood pressure reflexes elicited by low intensity stimulation of cutaneous and muscular afferents in cats.

The incidence and patterns of blood pressure reflexes elicited by sustained (3--4 min) low intensity electric stimulation (0.5--4 V, 0.1 ms, 4 Hz) of cutaneous and muscular afferents of high or low spinal segmental input levels were investigated in immobilized (gallamine) and artificially ventilated conscious or anaesthesized (chloralose-urethan) cats.

Characteristics of blood pressure and nictitating membrane reflexes elicited by electric stimulation of sciatic nerve in conscious and in anaesthetized cats.

Blood pressure (BP) reflexes and contractions of the nicitating membrane (NM) elicited by sustained (60 sec) stimulation of the sciatic nerve have been simultaneously recorded in gallamine immobilized conscious cats and following the administration of chloralose-urethane (50 and 300 mg/kg, respectively). By varying the stimulation parameters in a wide range, voltage and frequency characteristics of BP and NM reflexes have been plotted. In order to reduce the great number of possible BP-characteristics, the "dose" of stimulation (the product of voltage, impulse duration, frequency and of the stimulation period) has been introduced to plot "dose"-response curves.