Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism.

Objective: To explore the possible contribution of the apolipoprotein (apo) E polymorphisms to the extent and severity of coronary artery disease (CAD) related to lipid metabolism.

Methods: Overall, 53 Turkish patients, aged 54+/-11 years defined by coronary angiography were included in this cross-sectional study. Reardon's coronary artery scoring was used.

Evaluation of insulin resistance in normoglycemic patients with coronary artery disease.

Background: Insulin resistance is clearly associated with coronary artery disease (CAD) in diabetics. Insulin resistance may also be present in normoglycemic individuals, and some of these patients can be diagnosed as having metabolic syndrome (MS) according to various definitions. However, the relationship between hyperinsulinemia and CAD is obscure in normoglycemic individuals, especially in patients who do not meet the criteria for MS.