Clinical significance and potential mechanisms of and in squamous cell carcinoma of head and neck: a study based on TCGA and GEO.

Objective: To explore the clinical significance and mechanisms of altered miRNAs in squamous cell carcinoma of head and neck (SCCHN) and provide references for SCCHN diagnosis and prognosis.

Method: Differential expressed miRNAs (DEMs) in SCCHN were screened through gene expression omnibus (GEO) DataSets and verified by the cancer genome atlas (TCGA) database. Next, the overall survival analysis, receiver operating characteristics, and clinical correlation analysis were adopted to filter the miRNAs with diagnostic and prognostic values.

Expression and regulatory network of miRNAs in head and neck squamous cell carcinoma.

Background: Head and neck squamous cell carcinoma (HNSCC) has the sixth-highest incidence rate of all malignant tumors. The occurrence and progress of HNSCC are induced by extensive molecular changes, resulting in a poor prognosis. The present study aims to explore how altered microRNAs (miRNAs) and their co-expression networks of miRNAs-target mRNAs in HNSCC and to provide references for diagnosis and therapy research.