Difference in protective effects of three structurally similar flavonoid glycosides from Hypericum ascyron against H₂O₂-induced injury in H9c2 cardiomyoblasts.

According to previous studies, hyperoside possesses myocardial protective effects. To investigate whether isoquercitrin and isohyperoside have similar functions, the protective effects of isoquercitrin and isohyperoside against H2O2‑induced injury in H9c2 rat cardiomyoblasts were evaluated using a 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay. The mechanism of action was investigated by assessing the leakage of lactate dehydrogenase (LDH) of hyperoside and isoquercitrin‑pretreated H9c2 cardiomyocytes following H2O2‑induced injury, and examining their effects on the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) activity.

3-Methyl-1H-pyrrolo[2,1-c][1,4]oxazin-1-one.

In the title mol-ecule, C(8)H(7)NO(2), all the non-H atoms lie essentially in the same plane (r.m.s.