Publications by authors named "Erasmo De la Pena-Almaguer"

Article Synopsis
  • The study investigates the effectiveness of Quantitative Flow Ratio (QFR) as a method to evaluate non-culprit lesions (NCLs) in patients who have suffered a myocardial infarction (MI), comparing its performance to the traditional fractional flow reserve (FFR) method.
  • It involves a systematic review and meta-analysis of eight studies, comprising 713 patients and 920 vessels, yielding high diagnostic accuracy metrics for QFR, including an overall AUC of 0.941 and sensitivity of 87.3%.
  • The results indicate that QFR is a promising tool for assessing NCLs in MI patients, with recommendations for further multicenter studies to validate these findings.
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Despite the elevated mortality rates associated with high-risk pulmonary embolism (PE), this condition remains understudied. Data regarding the effectiveness and safety of invasive therapies such as venoarterial extracorporeal membrane oxygenation (VA-ECMO) in this patient population remains controversial. Here, we present the case of a 61-year-old male with high-risk PE associated with refractory cardiac arrest and cardiogenic shock who underwent a combination of extracorporeal cardiopulmonary resuscitation with VA-ECMO and pharmaco-invasive therapy (mechanical thrombi fragmentation plus lower alteplase dose), resulting in successful pulmonary reperfusion.

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Background And Aims: Chronic heart failure (CHF) represents a significant cause of morbidity and mortality globally. Metabolic maladaptation has proven to be critical in the progression of this condition. Preclinical studies have shown that irisin, an adipomyokine involved in metabolic regulations, can induce positive cardioprotective effects by improving cardiac remodeling, cardiomyocyte viability, calcium delivery, and reducing inflammatory mediators.

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The authors of the image chapters of the National Association of Cardiologists of Mexico (ANCAM) and the Mexican Society of Cardiology (SMC), as well as personnel from the Department of Medicine and Nutrition of the University of Guanajuato, together with prominent experts in cardiovascular imaging from Mexico, have collaborated in the review, analysis and expansion of the various health strategies published in the first year of the coronavirus disease 2019 (COVID-19) pandemic, to safely perform cardiac imaging studies. This update aims to reduce the risk of COVID-19 transmission among patients and health-care personnel in the CT, MRI, and nuclear cardiology services. This work was expanded with supplementary information available free of charge on the website www.

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Background: Fast-track worldwide reperfusion programs improve outcomes in ST-elevation myocardial infarction and stroke. Similar programs called Program Evaluation and Review Technique (PERT) focus on submassive and massive pulmonary embolism (PE) excluding deep venous thrombosis (DVT).

Methods: PREVENTION-team (Hospital Zambrano Hellion Venous Thromboembolism [VTE] Rapid Response).

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Objective: To correlate the left ventricular parameters obtained with 64-slice Volumetric Computed Tomography (VCT) with those obtained with the reference standard, cardiovascular magnetic resonance (CMR) imaging.

Methods: VCT and a 3.0T MRI scanner were used.

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Article Synopsis
  • A 34-year-old man experienced a near-fatal cardiac event and was admitted for further evaluation.
  • Initial tests, including an ECG and echocardiogram, returned normal results, raising initial concerns about his heart health.
  • However, advanced imaging techniques revealed significant artery obstruction caused by a thrombus, despite earlier findings of only mild coronary artery disease.
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A previously healthy young man presented with a 12-hour history of sudden dyspnea and severe chest pain at rest. Initial findings of physical examination, electrocardiogram and chest radiography showed typical pericarditis and clinical instability. Echocardiogram revealed small pericardial effusion with right ventricle dilatation.

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Aortic valve replacement accounts for a significant portion of cardiac surgeries in the United States. Despite advances in prosthetic heart valve design, surgical technique, and postoperative care, complications after aortic valve replacement remain a leading cause of morbidity and mortality. Routine surveillance of prosthetic heart valves with transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and fluoroscopy is important, as these techniques allow accurate detection of prosthetic valve dysfunction.

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Purpose: To determine prospectively the safety and efficacy of the blood-pool contrast agent gadofosveset trisodium in renal artery magnetic resonance angiography (MRA).

Materials And Methods: Gadofosveset (0.03 mmol/kg) was administered to adult patients with known or suspected renal arterial disease in a multi-center phase 3 single dose study.

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Article Synopsis
  • * Researchers conducted experiments on eight rabbits, imaging various phases of interventions like guidewire placement and stenting using a high-resolution MRI system.
  • * Results showed that real-time spiral MRI accurately identified aortic stenoses and successfully visualized interventional procedures, indicating its potential for guiding similar coronary interventions.
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Unlabelled: The evaluation of Left ventricular function has both prognostic as well as therapeutic implications in patients with heart disease. Non-invasive coronary angiography with computed tomography using 16 slices (MDCT-16) allows to obtain images of the coronary anatomy due to its high spatial and temporal resolution, and also, to obtain data regarding Left ventricular function. The objective of this study was to correlate the use of MDCT-16 for the evaluation of the Left ventricular parameters using MRI as the Standard of reference.

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Objectives: The purpose of this study was to investigate the use of coronary magnetic resonance angiography (MRA) for assessing human epicardial coronary artery vasodilation.

Background: Coronary vasodilation plays a vital role in the human coronary circulation. Previous studies of epicardial coronary vasodilation have used invasive coronary angiography.

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Myocardial reperfusion injury is defined as the adverse effects that ensue upon restoration of the circulation, which allows blood and nutrients to reach cells previously subjected to ischemia. Restoration of blood flow can be accompanied by the release of oxygen free radicals, the appearance of intracellular calcium overload, and alterations in cell metabolism -all situations that can give rise to functional or structural myocardial injury. Clinical signs of injury may appear after circulation is restored or after the use of extracorporeal circulation during heart surgery, and are manifested as stunned or hibernating myocardium after acute coronary syndromes, as the no-reflow phenomenon (microvascular injury) after blood flow is restored during angioplasty or after <>, and especially after surgical revascularization.

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Background: It is generally perceived that the persistence of ST segment depression for more than 5 min after treadmill exercise testing (ETT) signifies a strongly positive test and predicts more severe ischemia and coronary artery disease.

Aim: The aim of this study was to determine if prolonged ST segment changes (>5 min) after ETT identifies patients with more severe ischemia and thus severe coronary artery disease.

Methods: Twenty five patients (19 males, mean age 58+/-10 years) with >1 mm ST segment depression and recovery time 1 mm ST segment depression and recovery time >5 min (group 2) undergoing ETT and single photon emission computed tomography were prospectively enrolled.

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