Background: Numerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce.
Objective: We aimed to investigate the cognitive 10-year course of a cohort of MS patients.
Methods: 59 patients with clinically isolated syndrome (CIS) or relapsing-remitting (RR) MS were evaluated with Rao's Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later).
The study tested the cognitive reserve hypothesis by quantifying cognitive reserve (CR) and subsequently determining its role in executive function and verbal episodic memory performance. A neuropsychological battery was administered to 383 Greek-Cypriot older adults. A multiple indicators multiple causes (MIMIC) latent construct was utilized to define CR incorporating three indicators: years of education, vocabulary, and reading performance.
View Article and Find Full Text PDFObjective: To investigate the pattern of cognitive impairment in patients with relapsing-remitting (RR), secondary progressive (SP), primary progressive (PP) multiple sclerosis, and patients with clinically isolated syndrome (CIS) suggestive of MS, relative to control participants in the Greek population.
Methods: RR patients (N=75), SP patients (N=29), PP patients (N=23), CIS patients (N=33), and healthy control participants (N=43) were assessed by the Brief Repeatable Battery of Neuropsychological Tests (BRBN).
Results: The overall prevalence of cognitive dysfunction in our patients was 52.