Publications by authors named "Er-Fu Xie"
Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients.
World J Gastroenterol
August 2019
Background: Hepatitis B is a major public health problem in China. Accurate liver injury assessment is essential for clinical evidence-based treatment. Liver biopsy is considered the gold standard method to stage liver disease, but it is not widely used in resource-limited settings.
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- MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and play essential roles in cancer development, such as in non-small cell lung cancer (NSCLC).
- This study focused on miR-638, examining its expression in NSCLC cell lines and patient sera to evaluate its significance in predicting chemotherapy response and patient prognosis.
- Key findings indicated that higher levels of miR-638 after chemotherapy correlated with better survival rates, suggesting it could serve as an independent prognostic marker for NSCLC patients.
[Quantitative detection of APC/RASSF1A promoter methylation in the plasma of patients with cervical diseases].
Zhonghua Fu Chan Ke Za Zhi
December 2013
Objective: To quantitatively detect adenomatous polyposis coli(APC) and Ras association domain family 1A( RASSF1A) promoter methylation levels in the plasma of patients with cervical disease and to determine the diagnostic value of the indicators of cervical disease.
Methods: Preoperative blood samples were collected from 25 cases of healthy women and 118 cases of cervical disease, and tissue samples were also collected from 31 cases of them. The APC/RASSF1A promoter methylation levels of plasma and tissue were determined by duplex real-time quantitative methylation specific PCR (qMSP).
Background And Objective: The protein encoded by adenomatous polyposis coli (APC) gene participates in the signaling transduction pathway. Substantial studies have revealed that hypermethylation of APC gene promoter is closely related to the pathogenesis and development of cancer. This study was to develop a real-time quantitative methylation specific PCR (real-time QMSP) method, and detect the methylation of APC gene promoter in plasma of lung cancer patients.
View Article and Find Full Text PDFBackground & Objective: Hypermethylation of CpG islands in adenomatous polyposis coli (APC) gene has been detected in a variety of human tumors, which is involved in the pathogenesis of these tumors. In previous research, we detected APC promoter methylation in 47% lung tumor tissues. This study was to analyze the effect of APC promoter methylation on the gene transcription in 3 lung cancer cell lines.
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