Caesalpinbondin A, a Novel Diterpenoid Lactone With an Unprecedented Carbon Skeleton from the Seeds of .

One novel diterpenoid lactone named caesalpinbondin A () that possesses an unprecedented tetracyclic ring system in which a 6/6/5-fused tricyclic ring and a 4,5-dimethyldihydrofuran-2(3H)-one were connected by a C-C single bond comprising a 5-(naphtho [2,3-b]furan-7-yl)dihydrofuran-2(3H)-one moiety was isolated from the seeds of . Its chemical structure was established by extensive spectroscopic methods, and its absolute configuration was further determined by single-crystal X-ray diffraction analysis and electronic circular dichroism calculation. The biological evaluation suggested that compound demonstrated potent anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD .

Diterpenoids and C Nor-Isoprenoid Identified From the Leaves and Twigs of Activating Apoptosis and Pyroptosis.

(Family Euphorbiaceae) is an annual aromatic plant endemic to Yunnan Province, China, which yields an aromatic, spicy oil used as a flavoring and fragrance. The aim of the present study was to acquire secondary metabolites from the leaves and twigs of and to evaluate their cytotoxic activity. Five new diterpenoids, croyanhuins A-E (-), and one new C nor-isoprenoid, croyanhuin F (), were isolated from the leaves and twigs of .

Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus .

Two potential non-ribosomal peptide synthetases (NRPSs) were identified in the genome of a guanophilic fungus Amphichorda guana by bioinformatics analysis and gene knockout experiments. Liquid chromatography coupled with mass spectrometry (LC-MS) guided isolation led to the discovery of a new cyclodepsipeptide isaridin H (1) and seven known analogs, desmethylisaridin E (2), isaridin E (3), isariin A (4), iso-isariin B (5), iso-isariin D (6), isariin E (7), and nodupetide (8). The absolute configuration of isaridin H (1) was achieved by Marfey's method.

Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus.

A new p-terphenyl derivative aspergicandidusin A (1), a new cleistanthane diterpenoid 6-deoxyaspergiloid C (13), and 12 known compounds (2-12, and 14) were isolated from the mold Aspergillus candidus. The structures of the new compounds were elucidated by spectral analysis of NMR and MS data. The absolute configuration of C-1 in 13 was determined via the circular dichroism data of the [Rh(OCOCF)] complex.

-Terphenyls and actinomycins from a sp. associated with the larva of mud dauber wasp.

In the course of searching for cytotoxic metabolites from insects associated actinomyces, two new natural -terphenyl glycosides, strepantibin D () and strepantibin E (), along with terferol (), actinomycin D (), actinomycin V () and actinomycin V (), were identified from the fermentation medium of a sp. which was obtained from the larva body of mud dauber wasp. Strepantibin D (), previously reported as a synthetic derivative of terfestatin A, is firstly isolated as a natural -terphenyl in this research.

Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived sp.

Four angucycline glycosides were previously characterized from marine-derived sp. OC1610.4.

Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance.

Vibriosis is a major epizootic disease that impacts free-living and farmed fish species worldwide. Use of probiotics is a promising approach for prevention of Vibrio infections in aquaculture. A probiotic anti-Vibrio strain, Bacillus pumilus H2, was characterized, and the mechanism of its effect was investigated.

New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity.

Four new ambuic acid derivatives (1-4), and four known derivatives (5-8), were isolated from the solid culture of a plant pathogenic fungus Pestalotiopsis neglecta. Their structures were elucidated by extensive NMR experiments. The absolute configuration of the C-16 secondary alcohol in 1 was deduced via the CD data of the in situ formed [Rh2(OCOCF3)4] complex with the acetonide derivative of 1.

Depside α-glucosidase inhibitors from a culture of the mushroom Stereum hirsutum.

Nine new isoprenylated depsides, sterenins E-M (1-9), as well as five known compounds (10-14), were isolated from the solid culture of Stereum hirsutum. The structures of the new compounds were elucidated by spectroscopic methods. Their inhibitory activities against yeast α-glucosidase were evaluated in vitro.

Labdane diterpenoid glycosides from Aster veitchianus.

Four new labdane-type rhamnopyranosides derived from 13-epimanool, compounds 1-4, with differently acetylated sugar moieties, were isolated from A. veitchianus. Their structures and absolute configurations were elucidated by chemical transformation, spectroscopic and mass-spectrometric analyses (IR, 1D- and 2D-NMR, HR-ESI-MS), as well as by single-crystal X-ray diffraction (compound 1).

Five new iridoids from Patrinia rupestris.

Five new iridoids, namely rupesin A-E (1-5, resp.), together with six known iridoids, 6-11, were isolated from the roots of Patrinia rupestris. Their structures were elucidated by spectroscopic methods including IR, UV, MS, and 1D- and 2D-NMR experiments, and comparison with data of known analogues.

New eremophilenolides from Cacalia pilgeriana.

Five new eremophilenolides and a known sesquiterpene were isolated from the methanol extract of the roots of Cacalia pilgeriana. Their structures were identified as 1 beta-hydroxy-2 beta-methyl-senecioyloxyeremophil-7(11)-en-8 beta(12)-olide (1), 1 beta-hydroxy-2 beta-methylsenecioyloxy-8 alpha-methoxyeremophil-7(11)-en- 8 beta(12)-olide, 2 beta-hydroxy-3 beta-methylsenecioyloxyeremophil-7(11)-en-8 alpha(12)-olide ( 3), 2 beta,8 beta-dihydroxy-3 beta-methylsenecioyloxyeremophil-7(11)-en-8 alpha(12)-olide and 1 beta,8 beta-dihydroxy-2 beta,3 alpha-diangeloyloxyeremophil-7(11)-en-8 alpha(12)-olide ( 5) and caryolane-1,9 beta-diol by spectroscopic methods including 2D-NMR techniques ( (1)H- (1)H COSY, HMQC, HMBC) and HR-ESI-MS. The structure and relative stereochemistry of compound 1 were unequivocally established by X-ray diffraction analysis.

Two new compounds from Ligularia dolichobotrys.

Two new compounds, a stigmasterol (1) and an eremophilenolide (2), were isolated from Ligularia dolichobotrys (Diels) together with ten known sesquiterpenoids, two known triterpenes and five known sterols. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2D NMR). In addition, bakkenolide A (3) exhibited effective antitumor activity to human leukemia cells (HL-60), human hepatoma cells (Bel-7402) and human ovarian neoplasm cells (HO-8910).

Terpenes from Juniperus przewalskii and their antitumor activities.

Two new diterpenes were isolated from Juniperus przewalskii, together with 17 known terpense. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2DNMR). In addition, 3 alpha-hinokiol (3) and 3 alpha-hydroxymannol (9) exhibited effective antitumor activities to cervical carcinoma (HeLa) and human ovarian carcinoma (HO-8910) cell lines.