Factors affecting the ability of isolated Plasmodium knowlesi merozoites to attach to and invade erythrocytes.

Plasmodium knowlesi merozoites were prepared by the polycarbonate sieving method of Dennis, Mitchell, Butcher & Cohen (1975). Merozoite function was assayed by their attachment to and invasion of rhesus erythrocytes at 37 degrees C. The early merozoites from the culture chamber were the most invasive, although maximum numbers of merozoites appeared later.

Aspects of consumer satisfaction with brief family therapy.

In an evaluative study of brief family therapy, 279 families were administered a Family Satisfaction Questionnaire in their own homes, six months after treatment terminated. This questionnaire was designed to assess several aspects of the families' satisfaction with services received. The identified patient in all families was a child with academic and/or behavioral problems at school.

The role of goal attainment scaling in evaluating family therapy outcome.

The role of an individualized goal attainment procedure as an outcome measure for brief family therapy is described. Establishment of a scale and assessment of goal attainment at six-month follow-up are reported in a study of some 270 families. Results support the procedure as being a reliable and valid means of examining the outcome status of treated families.

The cytologic appearance of metastatic transitional cell carcinoma.

Seven cases with cytologic material from metastatic transitional cell carcinoma are presented. Three cellular patterns were seen: 1) papillary fragments, 2) cells with a moderate amount of dense cytoplasm and 3) undifferentiated malignant cells.

Adverse reactions to contrast media.

Two case histories are presented of patients having adverse reactions to urographic contrast media, one severe and the other fatal. The role of the family physician is stressed in communicating with consultants and the radiological department of the hospital to which patients are referred for contrast media studies.The patient's previous history of allergies, particularly sea food allergy, and any previous reaction to urographic contrast media are of great importance.

Primary papillary carcinoma of the prostate: report of a histopathologic, cytologic and electron microscopic study on one case.

An unusual type of prostatic carcinoma is described. Histopathologic examination showed a papillary and acinar appearance. Aspiration cytology showed papillary fragments and sheets of malignant cells.

Drug therapy in allergic disorders.

There are many drugs available to the physician treating allergic disorders, so it is very easy to become confused; therefore one must be selective, get to know a few drugs well, and know how and why to use a particular drug for a particular allergic disorder.

The family as a social unit.

Family medicine, in common with most other medical specialties, is passing through a period of lively debate concerning its course and development. This paper discusses that portion of the debate attempting to define the function of the family physician in overseeing the comprehensive and continuing health care of patients and their families. One consequence of such a definition is the need to understand thoroughly the family in its functional role as a social unit.

Prostatic biopsy. A morphologic correlation of aspiration cytology with needle biopsy histology.

One hundred and eighteen aspiration biopsies of the prostate are correlated with needle biopsies. The overall accuracy of the needle biospy is 85.6% and that of the aspirates is 86.

Prostatic carcinoma. Correlation of histologic features of prognostic value with cytomorphology.

Positive aspiration smears of 34 cases of histogically confirmed prostatic carcinoma were studied. Four features found to be of prognostic value in histologic material in a previous study--cell borders, lymphocytic infiltration, pleomorphism, and histologic typing of the tumor--were compared with the cytologic pattern present on the smears. Pleomorphism was the only feature for which good correlation was obtained between these two techniques.

Prostatic carcinoma: some morphological features affecting prognosis.

Morphologic features in 146 cases of prostatic carcinoma were correlated with 5-year survival. Simple probability tests showed a significant prognostic difference of the presence or absence of cell borders, lymphocytic infiltration, pleomorphism of nuclei, and McNeal's typing. Further statistical analysis, with a probability test which was adjusted for the distribution of these factors, showed that only the presence or absence of cell borders and lymphocytic infiltration affected prognosis.

Adverse and allergic reactions to drugs.

Six major mechanisms by which adverse reactions to drugs can occur are outlined, with special reference being made to drug allergy. The article also covers diagnostic procedures, factors influencing development of drug allergy, prevention of adverse reactions, and treatment of immediate allergic response. Physicians are urged to convey their findings to the Drug Adverse Reporting Program in Ottawa, while patients are encouraged to contact the Canadian Medic-Alert Foundation for the appropriate tag.

Predictions of therapeutic process and progress in conjoint family therapy.

Following initial diagnostic interviews with 20 families in an outpatient psychiatric clinic, a group of therapists made predictions of the anticipated responses of the families to therapy. Changes in family structure, organization, and transactional patterns were predicted with use of the Family Category Schema. The families' responses to the process of therapy was predicted in a questionnaire.

Practical rehabilitation of the chronic allergic patient.

This article describes the roles of the treatment team responsible for helping to rehabilitate chronic asthmatics at St. Joseph's Hospital in Toronto. The program can be set up in any local hospital currently having these personnel on staff, and does not require additional financial outlay.