Engaging patients in antimicrobial stewardship: co-designed educational tool to improve periprocedural care through de-implementation of guideline-discordant antimicrobial use.

Effective de-implementation models often include replacement of an ineffective practice with an alternative. We co-developed patient education materials as a replacement strategy for inappropriate post-procedural antibiotics in cardiac device procedures. Lessons learned and developed materials may be used to promote infection prevention in other periprocedural settings.

Factors associated with uptake of guideline-recommended cardiovascular implantable electronic device management: a nationwide, retrospective cohort study.

Clinical guidelines recommend device removal for cardiovascular implantable electronic device (CIED) infection management. In this retrospective, nationwide cohort, 60.8% of CIED infections received guideline-concordant care.

A Novel Informatics Tool to Detect Periprocedural Antibiotic Allergy Adverse Events for Near Real-time Surveillance to Support Audit and Feedback.

Importance: Standardized processes for identifying when allergic-type reactions occur and linking reactions to drug exposures are limited.

Objective: To develop an informatics tool to improve detection of antibiotic allergic-type events.

Design, Setting, And Participants: This retrospective cohort study was conducted from October 1, 2015, to September 30, 2019, with data analyzed between July 1, 2021, and January 31, 2022.

Promoting de-implementation of inappropriate antimicrobial use in cardiac device procedures by expanding audit and feedback: protocol for hybrid III type effectiveness/implementation quasi-experimental study.

Background: Despite a strong evidence base and clinical guidelines specifically recommending against prolonged post-procedural antimicrobial use, studies indicate that the practice is common following cardiac device procedures. Formative evaluations conducted by the study team suggest that inappropriate antimicrobial use may be driven by information silos that drive provider belief that antimicrobials are not harmful, in part due to lack of complete feedback about all types of clinical outcomes. De-implementation is recognized as an important area of research that can lead to reductions in unnecessary, wasteful, or harmful practices, such as excess antimicrobial use following cardiac device procedures; however, investigations into strategies that lead to successful de-implementation are limited.

The impact of school opening model on SARS-CoV-2 community incidence and mortality.

The role that traditional and hybrid in-person schooling modes contribute to the community incidence of SARS-CoV-2 infections relative to fully remote schooling is unknown. We conducted an event study using a retrospective nationwide cohort evaluating the effect of school mode on SARS-CoV-2 cases during the 12 weeks after school opening (July-September 2020, before the Delta variant was predominant), stratified by US Census region. After controlling for case rate trends before school start, state-level mitigation measures and community activity level, SARS-CoV-2 incidence rates were not statistically different in counties with in-person learning versus remote school modes in most regions of the United States.

Generation and characterization of iPSC lines from two nuclear envelopathy patients with a homozygous nonsense mutation in the TOR1AIP1 gene.

LAP1 is an inner nuclear membrane protein encoded by TOR1AIP1. A homozygous c.961C > T loss of function mutation in TOR1AIP1 that affects both isoforms of LAP1 was recently described.

The Impact of School Opening Model on SARS-CoV-2 Community Incidence and Mortality: A Nationwide Cohort Study.

The role that in-person schooling contributes to community incidence of SARS-CoV-2 infections and deaths remains unknown. We conducted an event study evaluating the effect of in-person school on SARS-CoV-2 cases and deaths per 100,000 persons during the 12-weeks following school opening, stratified by US Census region. There was no impact of in-person school opening and COVID-19 deaths.

Effectiveness of 3 Versus 6 ft of Physical Distancing for Controlling Spread of Coronavirus Disease 2019 Among Primary and Secondary Students and Staff: A Retrospective, Statewide Cohort Study.

Background: National and international guidelines differ about the optimal physical distancing between students for prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission; studies directly comparing the impact of ≥3 versus ≥6 ft of physical distancing policies in school settings are lacking. Thus, our objective was to compare incident cases of SARS-CoV-2 in students and staff in Massachusetts public schools among districts with different physical distancing requirements. State guidance mandates masking for all school staff and for students in grades 2 and higher; the majority of districts required universal masking.

[The functional characteristics of an additional dead space and a respirator for preparing hypoxic-hypercapnic mixtures intended for respiration training].

A study was made of the characteristics of respiration recorded during the use of a respirator for preparing hypoxic hypercapnic mixtures as compared to the use of an additional "dead" space. In both cases, there was a significant increase of total ventilation, largely at the expense of respiration deepening. However, during respiration via a respiratory mask, the increase of the minute respiratory volume was accompanied by a rise of alveolar ventilation whereas during respiration via the ADS, alveolar ventilation dropped.

[Polarographic evaluation of oxygen metabolism in the transplant after esophagogastroplasty].

Oxygen metabolism of a tube graft formed from the greater curvature of the stomach in esophagoplasty for carcinoma of the thoracic esophagus was studied by polarography. The study was conducted during the stages of treatment: in the early postoperative period and before the formation of a postponed extracavitary esophagogastric anastomosis. Oxygen tension (pO2) and the rate of oxygen consumption (ROC) by the graft tissue were studied.

[Replacement of defects in the dura mater with a siloxane elastomer].

The authors discuss the experimental data and information concerning the clinical use of a siloxane elastomer for repairing a defect in the dura mater in 40 patients with various cerebral pathology. Observation over the patients in postoperative periods of up to 34 months, the results of autopsy and repeated operations, and experimental data allow the suggested material to be considered quite adequate and possessing definite advantages over other materials used for the purpose.

[Late results of operations in patients with epilepsy with marked mental disorders].

The article reports data concerning 260 patients with epilepsy who were treated by different variants of operations on the open brain. The duration of the catamnesis ranged from 3 to 17 years. It is shown that the results of the treatment are determined by some initial data, in particular, the features of the psychopathological and neuropsychological disorders and their degree.

[Neuropsychological studies in the surgery of epilepsy].

Comparison of the findings of neuropsychological examination with the EEG pattern, the results of psychopathological examination, and the character of the paroxysms showed the high informativeness of standardized neuropsychological diagnostic methods in determining the location of the dominant epileptic focus and predicting the outcomes of surgical treatment of patients with epilepsy as well as the transient character of possible disorders of high cortical functions caused by surgical interventions.

[Ultrastructure of epileptic foci in temporal epilepsy].

An electron microscopy study was conducted on the material of biopsies from the removed epileptic foci localized in the hippocamp and fields 21 and 38 of the temporal cortex of 11 patients with temporal epilepsy. There was the constant presence of so-called dark and altered light neurocytes whose cytoplasm had experienced considerable changes and was saturated with various inclusions. The axons and dendrites of the cells underwent peculiar degeneration.

[Effect of a constant magnetic field on the respiration of human skin during reparative and destructive processes].

Effect of magnetophore applicators constant magnetic field (MACMF) on the functional state of human skin at reparative and destructive processes. It has been found in the investigations carried out during epidermatoplasty under the magnetic field effect on the reparation zone for 10--12 days that MACMF effect is of antihypoxic character and is manifested locally and only on a regenerating tissue. In the experiments on skin grafts exposed to magnetic field for 22--26 hours there was also found antihypoxic direction of MACMF effect expressed in the stabilization of tissue respiration, which points to the weakening of destruction.