One-Pot Deoxygenation and Substitution of Alcohols Mediated by Sulfuryl Fluoride.

Sulfuryl fluoride is a valuable reagent for the one-pot activation and derivatization of aliphatic alcohols, but the highly reactive alkyl fluorosulfate intermediates limit both the types of reactions that can be accessed as well as the scope. Herein, we report the SOF-mediated alcohol substitution and deoxygenation method that relies on the conversion of fluorosulfates to alkyl halide intermediates. This strategy allows the expansion of SOF-mediated one-pot processes to include radical reactions, where the alkyl halides can also be exploited in the one-pot deoxygenation of primary alcohols under mild conditions (52-95% yield).

One-Pot Substitution of Aliphatic Alcohols Mediated by Sulfuryl Fluoride.

The Mitsunobu reaction is a powerful transformation for the one-pot activation and substitution of aliphatic alcohols. Significant efforts have focused on modifying the classic conditions to overcome problems associated with purification from phosphine-based byproducts. Herein, we report a phosphine free method for alcohol activation and substitution that is mediated by sulfuryl fluoride.

One-Pot 1,1-Dihydrofluoroalkylation of Amines Using Sulfuryl Fluoride.

Sulfuryl fluoride, SOF, has been known and used as a fumigant for over 50 years but it has only recently gained widespread interest as a reagent for organic synthesis. Herein we report a novel application of sulfuryl fluoride gas in a new 1,1-dihydrofluoroalkylation reaction, which simply involves bubbling SOF through a solution of amine, 1,1-dihydrofluoroalcohol, and diisopropylethylamine. The reaction is successful for a wide range of primary and secondary amines, as well as several 1,1-dihydrofluoroalcohols, to afford the 1,1-dihydrofluoroalkylated amines in 42% to 80% isolated yields.

Xenon Difluoride Mediated Fluorodecarboxylations for the Syntheses of Di- and Trifluoromethoxyarenes.

XeF2 is demonstrated to be a more proficient fluorine-transfer reagent than either NFSI or Selectfluor in fluorodecarboxylations of both mono- and difluoroaryloxy acetic acid derivatives. This method efficiently converts a wide range of neutral and electron-poor substrates to afford the desired di- and trifluoromethyl aryl ethers in good to excellent yields. The purifications are facile, and the reaction times are less than 5 min, which makes these fluorodecarboxylations promising for future PET-imaging applications.

[Programmed irrigation and drainage in the treatment of patients with suppurative arthritis and intramedullary phlegmons].

Programmed irrigation and drainage were used in the process of treatment of 17 patients with purulent arthritis of the knee joint and talocrural articulation and of 13 patients with intramedullary phlegmons of the femoral, tibial and humeral bones. The programmed irrigation and drainage were proved to decrease the microbial dissemination of the wash liquid to 10 colony-forming units per 1 ml during 1-3 days. The method allowed to avoid synovectomy and resection of the joint in patients with purulent gonitis, to decrease the risk of appearance of secondary infections.

[Programmed irrigation and drainage in the treatment of patients with a local soft-tissue suppurative infection].

Treatment of 92 patients aged from 18 to 69 years with abscesses and phlegmons of soft tissues included programmed irrigation and drainage. Apparatuses with two-level programs were used. It was shown that programmed irrigation and drainage allowed microbial dissemination by wash liquid to be decreased to 10 colony-forming units per 1 ml during 3 days.

[The characteristics of the course of suppurative complications of gunshot wounds in Afghanistan and the unresolved problems of their prevention and treatment].

The article describes the reasons and the frequency of purulent complications in gunshot wounds in Afghanistan. The authors stress the role of primary surgical management of wounds in the prophylaxis of wound infection, show the trends towards the improvement of the first aid and primary medical care. The article studies the efficiency of physical methods in the management of wounds, such as treatment by the pulsed stream of liquid, active drainage, treatment in regulated air environment.

[Antibiotics in the treatment of wounds in the victims of the earthquake in the Armenian SSR].

Purulent wounds in 88 victims of the Armenian earthquake with the syndrome of long-term squeezing were examined microbiologically and the experience with using antimicrobial drugs for their treatment was analyzed. In all the cases microbial associations were detected, coliform and nonfermenting gram-negative bacilli, enterococci, anaerobes and yeast-like fungi being isolated from 80, 20, 15 and 25 per cent of the patients respectively. 130 bacterial strains were studied in detail.

[Pulse jet administration of liquid in the treatment of suppurative wounds].

The work presents data on dynamics of microbial dissemination of purulent wounds in the process of surgical treatment with an additional action of the beating jet of liquid and repeated treatment by the beating jet of antibiotics. An analysis of results of healing the wounds has shown efficiency of the method when finishing the surgical treatment of purulent wounds by putting sutures as well as by plastic closure of the wounds.

[Active drainage of a wound].

Experimental investigations of the authors have shown active drainage to be optimal at negative pressure in the wound not higher than 80 mm Hg. The application of active drainage in the treatment of 1369 patients has demonstrated the effectiveness of the method for prevention of local complications of the wound process.

[Pathogenesis of anemia after extensive operations on the lungs].

On the basis of studying the concentration and volume indices of the erythron, iron plasmic pool, proliferation activity of the erythron and iron kinetics in 137 patients operated for pulmonary diseases the authors note a depression of the bone marrow red stem as a characteristic feature of postoperative anemia. A scheme of the main steps of postoperative anemia is presented.