Catalytic Reversible (De)hydrogenation To Rotate a Chemically Fueled Molecular Switch.

We report here the development of a rotating molecular switch based on metal-catalyzed reversible (de)-hydrogenation. Under an argon atmosphere, acceptorless dehydrogenation induces a switch from an alcohol to a ketone, while reversing to a hydrogen pressure switches back the system to the alcohol. Based on a tolane scaffold, such reversible (de)-hydrogenation enables 180° rotation.

Dissipative Acid-Fueled Reprogrammable Supramolecular Materials.

Smart materials reversibly changing properties in response to a stimuli are promising for a broad array of applications. In this article, we report the use of trichloroacetic acid (TCA) as fuel to create new types of time-controlled materials switching reversibly from a gel to a solution (gel-sol-gel cycle). Applying various neutral amines as organogelators, TCA addition induces amine protonation, switching the system to a solution, while TCA decarboxylation over time enables a return to the initial gel state.

Trichloroacetic acid fueled practical amine purifications.

Amine purification have for long been dominated by tedious stepwise processes involving the generation of large amounts of undesired waste. Inspired by recent work on out of equilibrium molecular machinery, using trichloroacetic acid (TCA), we disclose a purification technique considerably decreasing the number of operations and the waste generation required for such purifications. At first, TCA triggers the precipitation of the amines through their protonated salt formation, enabling the separation with the impurities.

Chemically Fueled Three-State Chiroptical Switching Supramolecular Gel with Temporal Control.

The recent discovery of temporally controlled gels opens broad perspectives to the field of smart functional materials. However, to obtain fully operative systems, the design of simple and robust gels displaying complex functions is desirable. Herein, we fuel dissipative gelating materials through iterative additions of trichloroacetic acid (TCA).

Umpolung Reactivity of in Situ Generated Phosphido-Boranes: An Entry to P-Stereogenic Aminophosphine-Boranes.

The synthesis of P-stereogenic aminophosphine-boranes has been developed on the basis of umpolung reactivity of in situ generated alkylarylphosphido-boranes, which are normally configurationally unstable intermediates. In our case, their high configurational stability was due to the slow release of the hydroxyalkyl protecting group, together with the fast formation of the iodophosphanylborane in the presence of N-iodosuccinimide. The subsequent substitution reaction was found to proceed in moderate to good yields and in a very high stereospecifity (es) using a variety of amines as nucleophiles.

Serious Gaming to Support Exercise Therapy for Patients with Chronic Nonspecific Low Back Pain: A Feasibility Study.

Objective: To investigate the feasibility of a functional exercise program supported by serious gaming for patients with chronic nonspecific low back pain (LBP).

Methods: Ten patients with chronic nonspecific LBP and an underlying motor control impairment were recruited. Subjects performed a partially supervised exercise program (36 sessions, 18 weeks) that included 30 minutes of general conditioning and 90 minutes of individually tailored functional motor control exercises (MCEs).

Feasibility of high intensity training in nonspecific chronic low back pain: A clinical trial.

Background: Although low to moderate intensity exercise therapy is a predominant part of rehabilitation in nonspecific chronic low back pain (NSCLBP), effect sizes are small and optimal exercise modalities/intensities are unclear. Conversely, effects of high intensity training have not yet been investigated in this population.

Objective: The aim of this study is to investigate the feasibility of high intensity training (HIT) and to explore the magnitude of the effects of a HIT program on exercise capacity and disease related outcome measures compared to conventional therapy for persons with NSCLBP.

Skill training preferences and technology use in persons with neck and low back pain.

Background: Neck pain (NP) and low back pain (LBP) are highly prevalent. Exercise therapy helps, but effect sizes and therapy compliance remain low. Client-centred therapy and technology use may play a role to improve therapy outcomes.