Ultrafast self-healing zwitterionic hydrogels reinforced by carboxymethyl chitosan-oxidized hyaluronic acid and graphene oxide toward high-performance strain sensors.

Inspired by the inherent recuperative ability of organisms in nature, researchers have dedicated significant efforts towards developing self-healing hydrogel sensors. Although the works on self-healing hydrogels have made great progress, achieving hydrogel sensors combining with rapid and efficient healing capability, excellent mechanical properties and high sensing sensitivity remains a challenging task. In this study, we proposed a novel approach for fabricating a self-healing conductive zwitterionic hydrogel sensor by adding carboxymethyl chitosan (CMCs) and oxidized hyaluronic acid (OHA) to induce dynamic Schiff base reaction, and graphene oxide (GO) nanosheets as physical crosslinker.

Integrated Multi-Omics Analyses Reveal Lipid Metabolic Signature in Osteoarthritis.

Osteoarthritis (OA) is the most common degenerative joint disease and the second leading cause of disability worldwide. Single-omics analyses are far from elucidating the complex mechanisms of lipid metabolic dysfunction in OA. This study identified a shared lipid metabolic signature of OA by integrating metabolomics, single-cell and bulk RNA-seq, as well as metagenomics.

Juvenile chronic social defeat stress reduces prosocial behavior in adult male mice.

Exposure to stress in early life can have a significant impact on individuals. However, the effects of early-life stress (ELS) on prosocial behavior remain unclear, as do the underlying mechanisms. In this study, ICR juvenile mice were subjected to juvenile chronic social defeat stress (jCSDS) between postnatal days 32 and 41, during which body weight changes were continuously monitored.

Investigating enhancement of protease and lysozyme combination pretreatment on hydrolysis of sludge organics under humic acid inhibition.

This study investigated the impact of humic acid (HA) on enzymatic pretreatment efficiency, focusing on sludge properties and HA molecular structure. The results showed that enzymatic pretreatment alleviates HA inhibition, improving hydrolysis efficiency. In the presence of HA, soluble proteins and polysaccharides in the enzyme-cocktail group reached 27.

Construction and characterization of a novel secreted MsC-CAR-T cell in solid tumors.

The CD47-SIRPα signaling has been acknowledged as a significant immune checkpoint and CD47 blocking has been proved as a potential therapeutic strategy for the treatment of solid tumor. However, the potential application of CAR-T cells secreted antibody fragment simultaneously in solid tumor is rarely explored. In this study, we searched bioinformatic databases and investigated the characteristics of CD47 in solid tumors.

Boosting effect of ultrasonication on the oxygen evolution reaction during zinc electrowinning.

In this study, the electrochemical and anodic behaviors of Pb-Ag anodes during ultrasound-assisted zinc electrowinning were meticulously examined. The oxygen evolution reaction (OER) occurring at the Pb-Ag anodes in a 150 g L aqueous HSO solution was studied in the absence (silent) and presence of ultrasonication (40 kHz, 100 % acoustic amplitude). Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), linear sweep voltammetry (LSV), and zinc electrowinning tests were conducted to analyze the electrochemical behavior of the Pb-Ag anodes during zinc electrowinning.

One-step green hydrometallurgical recycling of spent lithium-ion batteries' cathode.

The transition towards a low-carbon future hinges on the advancement of Lithium-ion battery (LIBs) technology, which has spurred a significant demand for raw materials and the management of waste batteries containing hazardous substances. Developing efficient and environmentally friendly recycling strategies is essential to tackle these challenges. Here, we introduce a one-step green hydrometallurgical recycling of spent lithium-ion batteries' cathode on the basis of contact-electro-catalytic (CEC) process.

Dual-bioinspired Janus mesh membrane with controllable bubbles manipulation property for efficient water splitting and pure gas collection.

Water splitting, as a promising clean energy source, has garnered significant attention owing to the escalating global energy crisis. However, prior research has largely focused on electrode materials rather than bubble manipulation, which plays a crucial role in the process. Although using the previously published "Releasing strategy" effectively eliminates micro-sized bubbles from the electrode material for efficient water splitting, the released tiny-sized bubbles pose challenges for controllable and pure collection.

Effects of drought stress on the secondary metabolism of Scutellaria baicalensis Georgi and the function of SbWRKY34 in drought resistance.

The pharmacological properties of the dried root of Scutellaria baicalensis Georgi, a Chinese medicinal herb, include antioxidant, antibacterial, and antiviral effects. In S. baicalensis quality assessment, concentrations of baicalin, wogonoside, baicalein, and wogonin in the root are crucial.

Metasurface spectrometers beyond resolution-sensitivity constraints.

Conventional spectrometer designs necessitate a compromise between their resolution and sensitivity, especially as device and detector dimensions are scaled down. Here, we report on a miniaturizable spectrometer platform where light throughput onto the detector is instead enhanced as the resolution is increased. This planar, CMOS-compatible platform is based around metasurface encoders designed to exhibit photonic bound states in the continuum, where operational range can be altered or extended simply through adjusting geometric parameters.

Control strategy of the novel stator free speed regulating wind turbine generation system.

Building a high-proportion renewable energy power system is a key measure to address the challenges of the energy revolution and climate change. However, current high-proportion renewable energy systems face issues of frequency instability and voltage fluctuations. To address these challenges, this paper proposes a novel topology for a stator free speed regulating wind turbine generation system.

Five-Year Incidence of Age-Related Macular Degeneration and Its Risk Factors in Adult Chinese Population: The Tongren Health Care Study.

Purpose: To examine the 5-year incidence of age-related macular degeneration (AMD) and its associated factors in an adult Chinese population.

Methods: The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital. Baseline examinations were performed from 2014 to 2015, with 5-year follow-up examinations conducted between 2019 and 2020.

Land cover change and its driving factors in Siberia from 1992 to 2020.

Siberia occupies vast areas underlain by permafrost, and understanding its land cover changes is important for ecological environmental protection in a warming climate. Based on the land cover and climate datasets, we analyzed the land cover changes and their drivers in Siberia from 1992 to 2020. The results show that ① From 1992 to 2020, the areas of evergreen needleleaf trees and deciduous needleleaf trees in Siberia decreased by 9% and 2.

Organic-inorganic complex S-scheme photocatalyst resorcinol-formaldehyde resins/BiOCO with enhanced photocatalytic HO production.

Herein, resorcinol formaldehyde resins/BiOCO S-scheme heterojunctions are constructed polymerization. The composites displayed an improved separation efficiency of photo-induced carriers and the HO production rate achieved 1178.08 μmol h g, marking 47.

Itaconic Acid Oligomers for Electrostatically Spun Degradable Implantable Biobased Polyurethane.

Developing implantable medical materials with excellent comprehensive performance has important practical applications. Cardiovascular and bile ducts are characterized by various forms of diseases and high morbidity and mortality. One of the effective treatment modalities for such diseases is replacement surgery.

Manipulating Electron-Phonon Coupling for Efficient Tin Halide Perovskite Blue LEDs.

Low-dimensional perovskites have opened up a new frontier in light-emitting diodes (LED) due to their excellent properties. However, concerns regarding the potential toxicity of Pb limited their commercial development. Sn-based perovskites are regarded as a promising candidate to replace Pb-based counterparts, while they generally exhibit strong electron-phonon coupling and consequently blue emission quenching at room temperature (RT), thus the Sn-based perovskite blue LED devices have not yet been reported.

Spectrum of DNA variants for patients with hearing loss in 4 language families of 15 ethnicities from Southwestern China.

Hearing loss is a common disease. More than 100 genes have been reported to be associated with hereditary hearing loss. However, the distribution of these genes and their variants across diverse populations remains unclear.

Relationship between EZH2 expression and prognosis of patients with hepatocellular carcinoma using a pathomics predictive model.

Background: Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) is overexpressed in hepatocellular carcinoma, promoting tumorigenesis and correlating with poor prognosis. Traditional histopathological examinations are insufficient to accurately predict hepatocellular carcinoma (HCC) survival; however, pathomics models can predict EZH2 expression and HCC prognosis. This study aimed to investigate the relationship between pathomics features and EZH2 expression for predicting overall survival of patients with HCC.

Establishment of RNA modification regulators index predicting clinical outcomes and immune relevance of kidney cancer patients.

Increasing evidence indicates that RNA modifications are misregulated in human cancers, which might be optimal targets of cancer therapy. However, important RNA regulators in kidney cancer still need further exploration. In this study, we collected regulators representing different types of RNA modification and identified the prognosis-related RNA regulators in kidney cancer patients.

Endemic species in the high Himalayas, Eastern Nepal, seeking conservation.

Prunus species play an important role in preserving the Nepal's unique identity; such as three endemic species of Prunus, , , and , represent the country's local area. An ecological and social survey of . and .

Association between cyclin-dependent kinase 4/6 inhibitors and nephrotoxicity in patients with breast cancer: A Systematic Review and meta-analysis.

Nephrotoxic adverse events (AEs) have been observed in patients with breast cancer receiving cyclin-dependent kinase (CDK) 4/6 inhibitors. This study aimed to evaluate the risk of nephrotoxicity associated with these inhibitors through a meta-analysis of 17 randomized controlled trials involving 19,638 patients. The results indicate a significant increase in all-grade nephrotoxic AEs, including elevated blood creatinine levels, acute kidney injury, and renal impairment (RR = 3.

Comparative genomics analysis of the MYB gene family in barley: preliminary insights into evolution and biological function in Blue Qingke.

Background: The Myeloblastosis related (MYB) family is one of the most widely distributed transcription factor families in plants and plays a significant role in plant growth and development, hormone signal transduction, and stress response. There are many reports on MYB family species, but the research on Qingke is still limited.

Methods: This study used comparative genomics methods to analyze gene and protein structure, protein physicochemical properties, chromosome localization, and evolution.