Publications by authors named "Enting Zhang"
Article Synopsis
- Dysfunctional CD8 T-cells in the nasopharyngeal carcinoma (NPC) tumor environment hinder the effectiveness of immunotherapies like anti-PD-L1, prompting the need for reliable markers to predict treatment success.
- This study investigates the role of the protein EIF3C in NPC by analyzing immune cell infiltration and correlating its expression with various CD8 T-cell markers, ultimately leading to the development of the EIF3C-related CD8 T-cell signature (ETS).
- Findings indicate that low EIF3C expression is linked to higher CD8 T-cell infiltration, and the ETS model successfully predicts prognosis and immunotherapy response in NPC patients, highlighting EIF3C's importance in NPC progression and immune modulation.
Purpose: To estimate the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and to evaluate the associations between thyroid parameters, MAFLD and liver fibrosis in euthyroid patients with newly diagnosed type 2 diabetes mellitus (T2DM).
Methods: Overall, 776 patients with newly diagnosed T2DM and 120 subjects without diabetes were included. All the participants were euthyroid, and were categorized as non-MAFLD and MAFLD.
(20S) ginsenoside Rh2 (G-Rh2), a major bioactive metabolite of ginseng, effectively inhibits the survival and proliferation of human liver cancer cells. However, its molecular targets and working mechanism remain largely unknown. Excitingly, we screened out heat shock protein 90 alpha (HSP90A), a key regulatory protein associated with liver cancer, as a potential target of (20S) G-Rh2 by phage display analysis and mass spectrometry.
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