Multifunctional Modified Tumor Cell Membranes-Coated Adjuvant PTX against Melanoma.

Melanoma is the deadliest type of skin cancer. Anti-tumor immunotherapy has made great progress in increasing the overall survival of patients. However, many physiological barriers cause low bioavailability of drugs.

Multi-functional nanocomplex codelivery of Trp2 and R837 to activate melanoma-specific immunity.

Antigen-adjuvant combination could induce a protective and long-lasting anti-tumor immune response. However, exploiting system which could co-deliver melanoma antigen peptide Trp2 (Tyrosinase-related protein 2) and Toll-like-receptor-7 (TLR7) agonists imiquimod (R837) both are poor aqueous solubility is still challenging. Our new nanocomplex was explored for specific delivery of Trp2 and R837 into antigen-presenting cells (APCs).

Chemical Profile and Anti-inflammatory Activity of Total Flavonoids from Fisch.

Fisch. () is one of the most widely used herbal medicines. This study was designed to enrich total flavonoids (TFF) from .