Antibacterial and Antibiofilm Efficacy of Copper-Doped Phosphate Glass on Pathogenic Bacteria.

Unlabelled: This study aimed to investigate the antibacterial [minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC)] and antibiofilm activity [log10 colony forming unit/mL (CFU/mL) and biofilm disruption] of copper-doped phosphate glass (CDPG) against and .

Methods: the antibacterial activity was determined using microbroth dilution and time-kill assay. The antibiofilm activity was investigated using crystal violet and confocal laser scanning microscopy.

Superfast Set, Strong and Less Degradable Mineral Trioxide Aggregate Cement.

Purpose: Despite the good sealing ability and biocompatibility of mineral trioxide aggregate (MTA), its slow setting, high degradation, and weakness limit its use in surgical endodontics and high stress-bearing areas. This study aimed to develop two new liquids to control these drawbacks. They were prepared from calcium chloride, fumed silica, and hydroxyapatite or calcium phosphate and coded "H" and "P," respectively.

Setting kinetics and mechanical properties of flax fibre reinforced glass ionomer restorative materials.

Regardless of the excellent properties of glass ionomer cements, their poor mechanical properties limit their applications to non-load bearing areas. This study aimed to investigate the effect of incorporated short, chopped and randomly distributed flax fibers (0, 0.5, 1, 2.

Demineralization-remineralization dynamics in teeth and bone.

Biomineralization is a dynamic, complex, lifelong process by which living organisms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization.

Nanotechnology in dentistry: prevention, diagnosis, and therapy.

Nanotechnology has rapidly expanded into all areas of science; it offers significant alternative ways to solve scientific and medical questions and problems. In dentistry, nanotechnology has been exploited in the development of restorative materials with some significant success. This review discusses nanointerfaces that could compromise the longevity of dental restorations, and how nanotechnolgy has been employed to modify them for providing long-term successful restorations.

The future perspectives of natural materials for pulmonary drug delivery and lung tissue engineering.

Introduction: Search for new, functional biomaterials that can be used to synergistically deliver a drug, enhance its adsorption and stimulate the post-injury recovery of tissue function, is one of the priorities in biomedicine. Currently used materials for drug delivery fail to satisfy one or more of these functionalities, thus they have limited potential and new classes of materials are urgently needed.

Areas Covered: Natural materials, due to their origin, physical and chemical structure can potentially fulfill these requirements and there is already strong evidence of their usefulness in drug delivery.

Tissue engineering in dentistry.

Objectives: of this review is to inform practitioners with the most updated information on tissue engineering and its potential applications in dentistry.

Data: The authors used "PUBMED" to find relevant literature written in English and published from the beginning of tissue engineering until today. A combination of keywords was used as the search terms e.

Biological performance of titania containing phosphate-based glasses for bone tissue engineering applications.

The interplay between glass chemistry, structure, degradation kinetics, and biological activity provides flexibility for the development of scaffolds with highly specific cellular response. The aim of this study was therefore to investigate the role of titania inclusion into the phosphate-based glass on its ability to stimulate osteoblast-like human osteosarcoma (HOS) cells to adhere, proliferate and differentiate. In depth morphological and biochemical characterisation was performed on HOS cells cultured on the surface of glass discs.

Control of surface free energy in titanium doped phosphate based glasses by co-doping with zinc.

To significantly improve the biocompatibility of titanium doped phosphate based glasses, codoping with zinc has been attempted. This study investigated the effect of doping a quaternary 15Na(2)O:30CaO:5TiO(2):50P(2)O(5) glass with zinc oxide (1, 3, and 5 mol %) on bulk, structural, surface, and biological properties; the results were compared with glasses free from ZnO and/or TiO(2). ZnO as adjunct to TiO(2) was effective in changing density, interchain bond forces, degradation behavior, and ions released from the degrading glasses.

Effect of surface treatment on the bioactivity of nickel-titanium.

In this paper, the bioactive properties of Ni-Ti alloy after different surface treatments were evaluated in different media (Hanks' balanced salt solution, Dulbecco's modified Eagle's medium and osteogenic). Evaluation was performed on the basis of X-ray photoelectron spectroscopy and atomic force microscopy studies after immersing samples for up to 24h in the relevant media. This allowed assessment of the kinetics of Ca(2+) and P(5+) precipitation and early interaction of the media with surfaces.

Effect of increasing titanium dioxide content on bulk and surface properties of phosphate-based glasses.

There is an ingoing need for more effective and less costly bone substitute materials. In a previous study, addition of titanium dioxide (TiO2) up to 5 mol.% was shown to be effective in controlling glass degradation, and this was reflected in enhanced gene expression and bone-forming capacity of phosphate-based glasses.

Nanomechanical evaluation of nickel-titanium surface properties after alkali and electrochemical treatments.

In this paper, the suitability of alkali treatment followed by heat treatment at 600 degrees C, and spark oxidation for nickel-titanium, intended for medical applications such as pins, wires and clamps, was evaluated on the basis of nanomechanical and wear testing. In addition, the chemical composition and topography of the surface layer, wetting ability, corrosion resistance and influence of the heat treatment on structure of the alloy were also investigated. The results showed that the highest hardness was observed for alkali-treated samples, and this could be correlated with the structure of the sample that contained martensite and a higher phase transformation temperature.

Processing, characterisation, and biocompatibility of zinc modified metaphosphate based glasses for biomedical applications.

Bulk and structural properties of zinc oxide (0 up to 20 mol%) containing phosphate glasses, developed for biomedical applications, were investigated throughout this study using differential thermal analysis (DTA), differential scanning calorimetry, X-ray powder diffraction and 31P and 23Na MAS NMR. Surface wettability and MG63 viability were also considered for surface characterisation of these glasses. The results indicated that incorporation of zinc oxide as a dopant into phosphate glasses produced a significant increase in density; however, the thermal properties presented in glass transition, and melting temperatures were reduced.

In vitro bioactivity and gene expression by cells cultured on titanium dioxide doped phosphate-based glasses.

In our previous study, glasses with 50 P(2)O(5)-(20-15) Na(2)O-30 CaO-(0-5 mol%) TiO(2) have been prepared by the conventional melt-quenching process. MG63 cell proliferation, gene expression, in vivo biocompatibility, and bioactivity of these glasses is the concern of this study. The results showed that addition of TiO(2) in small amounts up to 5 mol% enhanced the biocompatibility of these glasses.