Publications by authors named "Enrique-Maria Ocio"
Although it is known that increasing age is associated with increased morbidity and mortality in allogeneic transplantation (allo-HSCT), individualization of the process may allow to perform it in progressively older patients.This study analyzed the outcome of 97 patients older than 60 years with a first allo-HSCT performed at our institution between 2011 and 2019.Median age was 66 years (range 60-79) and 15.
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- Deletion of the long arm of chromosome 6 (del6q) is commonly found in Waldenström macroglobulinaemia (WM), present in about 50% of patients, but its impact on patient outcomes is not fully understood.
- In a study of 225 patients with immunoglobulin M (IgM) monoclonal gammopathies, del6q was more prevalent in symptomatic WM (30%) compared to asymptomatic WM (9%) and IgM-monoclonal gammopathy of undetermined significance (4%).
- Patients with del6q experienced worse prognostic features, quicker transitions to symptomatic disease, shorter progression-free survival, and reduced overall survival, suggesting that del6q is linked to poorer outcomes in
Multiple myeloma (MM) remains as an incurable disease and, although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative approach, most patients ultimately relapse, and their treatment remains challenging. Because allo-HSCT can modify not only the biology of the disease, but also the immune system and the microenvironment, it can potentially enhance the response to rescue therapies. Information on the efficacy and safety of novel drugs in patients relapsing after allo-HSCT is lacking, however.
View Article and Find Full Text PDFRecovery of polyclonal immunoglobulins one year after autologous stem cell transplantation as a long-term predictor marker of progression and survival in multiple myeloma.
Haematologica
May 2017
Immunoparesis or suppression of polyclonal immunoglobulins is a very common condition in newly diagnosed myeloma patients. However, the recovery of polyclonal immunoglobulins in the setting of immune reconstitution after autologous stem cell transplantation and its effect on outcome has not yet been explored. We conducted this study in a cohort of 295 patients who had undergone autologous transplantation.
View Article and Find Full Text PDFPrimary cutaneous plasmacytoma should be in the differential diagnosis in case of solitary or multiple erythematous-violaceous nodules or papules. The diagnosis relies on clinical, histological, and immunochemical findings, without underlying evidence of multiple myeloma. Treatment should be individualized, and agents such as bortezomib or lenalidomide have shown to be effective.
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