Publications by authors named "Enrique Olguin-Martinez"
IL-9 is a pleiotropic cytokine associated with various processes, including antitumor immunity, induction of allergic pathologies, and the immune response against helminth infections, where it plays an important role in the expulsion of the parasite. In a murine model of Nippostrongylus brasiliensis infection, IL-9 is produced mainly by CD4+ T lymphocytes and innate lymphoid cells found in the lung, small intestine, and draining lymph nodes. Given the technical difficulties involved in the intracellular staining of IL-9, as well as the complexity of isolating hematopoietic cells from the small intestine upon infection, there is a pressing need for a comprehensive but straightforward protocol to analyze the expression of IL-9 in different lymphoid and non-lymphoid tissues in this model.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 Innate Lymphoid Cells (ILC2s) are important immune cells that respond to tissue damage and regulate immunity against parasites and allergies by producing cytokines like IL-9, but the mechanisms behind IL-9 expression in ILC2s are not well understood.
- Recent research identified that in mice, ILC2s can be categorized based on IL-9 and ST2 expression, with distinct populations found in the lungs and small intestine, influenced by various stimuli, including the alarmin IL-33.
- The study discovered that the PKA pathway interacts with IL-33 to enhance IL-9 production and influence ILC2 function, highlighting the complexity and variability of ILC2 subsets and their potential therapeutic
Innate lymphoid cells (ILCs) are the most recently described group of lymphoid subpopulations. These tissue-resident cells display a heterogeneity resembling that observed on different groups of T cells, hence their categorization as cytotoxic NK cells and helper ILCs type 1, 2 and 3. Each one of these groups is highly diverse and expresses different markers in a context-dependent manner.
View Article and Find Full Text PDF