Publications by authors named "Enrique M Carrera"

Article Synopsis
  • Dietary restriction (DR) can improve lifespan and healthspan, but individual responses depend on genetics, particularly metabolism-related variations.
  • The study analyzed data from Drosophila and human cohorts to understand how different genotypes respond to dietary changes, using computational methods like random forest modeling and Mendelian randomization.
  • Key findings include the identification of specific metabolites (like orotate and threonine) that affect lifespan and healthspan traits, suggesting potential therapeutic pathways for diet-based interventions.
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Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies.

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Tauopathies encompass a range of neurodegenerative disorders, such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). Unfortunately, current treatment approaches for tauopathies have yielded limited success, underscoring the pressing need for novel therapeutic strategies. We observed distinct signatures of impaired glycogen metabolism in the brain of the tauopathy model and the brain of AD patients, indicating a link between tauopathies and glycogen metabolism.

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Biological age, distinct from an individual's chronological age, has been studied extensively through predictive aging clocks. However, these clocks have limited accuracy in short time-scales. Here we trained deep learning models on fundus images from the EyePACS dataset to predict individuals' chronological age.

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