The article focuses on preparing a nanoformulation based on hydrotalcite and glycyrrhizic acid (GA), seeking a hepatoprotective effect. For this purpose, hydrotalcite-GA formulations were prepared by varying the following conditions to obtain optimal systems in terms of size and PDI (the lowest values), and Z potential (the highest values): (i) type of hydrotalcite (obtained by co-precipitation or calcined hydrotalcite); method used (ultrasound or high shear stirring), and (iii) type of stabilizer (Tween®80 or Pluronic® F-127). The best results were obtained using hydrotalcite obtained by co-precipitation, with high shear stirring and adding a stabilizer, either Tween®80 (HT-T80-GA: mean particle size = 315 nm, PDI = 0.
View Article and Find Full Text PDFThe first experimental investigation of a porous organic cage (POC) for the challenging task of HS capture is reported. The N-containing cage molecular material, a tertiary amine POC (6FT-RCC3), demonstrates the highest HS (hydrogen sulfide) capture (record capacity) for a porous material at room temperature and atmospheric pressure (20.6 mmol HS g; 25 HS molecules per cage) combined with excellent reversibility for at least five adsorption-desorption cycles.
View Article and Find Full Text PDFCopper deficiency can trigger various diseases such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease (PD) and even compromise the development of living beings, as manifested in Menkes disease (MS). Thus, the regulated administration (controlled release) of copper represents an alternative to reduce neuronal deterioration and prevent disease progression. Therefore, we present, to the best of our knowledge, the first experimental investigation for the kinetics of copper release from MOF-74(Cu) and its distribution after oral administration in male Wistar rats.
View Article and Find Full Text PDFChem Commun (Camb)
October 2023
The recent development and implementation of copper-based metal-organic frameworks in biological applications are reviewed. The advantages of the presence of copper in MOFs for relevant applications such as drug delivery, cancer treatment, sensing, and antimicrobial are highlighted. Advanced composites such as MOF-polymers are playing critical roles in developing materials for specific applications.
View Article and Find Full Text PDFA non-porous version of SU-101 (herein n-SU-101) was evaluated for the CO cycloaddition reaction. The findings revealed that open metal sites (Bi) are necessary for the reaction. n-SU-101 displays a high styrene oxide conversion of 96.
View Article and Find Full Text PDFA rich plethora of information about grafted chitosan (CS) for medical use has been reported. The capability of CS-grafted poly(N-hydroxyethyl acrylamide) (CS-g-PHEAA) to support human dermal fibroblasts (HDFs) in vitro has been proven. However, CS-grafted copolymers lack good stiffness and the characteristic microstructure of a cellular matrix.
View Article and Find Full Text PDFLinezolid (LNZ) is a new-generation synthetic molecule for the antibacterial treatment of severe infections, particularly in infective cases where the bacterial resistance to first-choice drugs is caused by Gram-positive pathogens. In this context, since 2009, some strains resistant to LNZ in patients with long-term treatments have been reported. Therefore, there is a need to use not only new drug molecules with antibacterial activities in the dosage form but also a different approach to pharmacotherapeutic strategies for skin infections, which lead to a reduction in the concentration of biocides.
View Article and Find Full Text PDFThe design of controlled grafting copolymers is critical in synthesizing effective artificial cellular matrices because of their regulatory role in cellular behavior. However, it is unclear whether poly(2-aminoethyl methacrylate) grafted onto chitosan generated by gamma-radiation-induced graft polymerization in different solvents can influence the physicochemical properties and biotech applicability of the copolymer. This work aims to demonstrate for the first time the effect of various solvents on the synthesis, properties, and biological performance of grafted chitosan using the simultaneous irradiation method.
View Article and Find Full Text PDFTwo fluorinated γ-AlO series were synthesized by a sol-gel method with two solvents (2-propanol and 2-butanol), two aluminium sources (ATB and ATP) and one fluorine source (NaAlF). The resulting inorganic matrixes were evaluated to characterize aluminium and fluorine species ([AlO], [AlO], [AlO], [AlF], [AlF] and [AlF]) by powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Al magic angle spinning nuclear magnetic resonance (Al MAS-NMR) and infrared spectroscopy (IR-ATR). BET and BJH analyses using the nitrogen isotherms of these materials allowed identifying a clear trend in some textural parameters such as specific surface area and fluorine content.
View Article and Find Full Text PDFCarbon capture utilisation and storage (CCUS) using solid sorbents such as zeolites, activated carbon and Metal-Organic Frameworks (MOFs) could facilitate the reduction of anthropogenic CO concentration. Developing efficient and stable adsorbents for CO capture as well as understanding their transport diffusion limitations for CO utilisation plays a crucial role in CCUS technology development. However, experimental data available on CO capture and diffusion under relevant industrial conditions is very limited, particularly for MOFs.
View Article and Find Full Text PDFMolecular dynamics simulations reveal the behavior of the bimodal distribution of cation conformations (folded/unfolded) in ionic liquids based on alkylated imidazoles, such as [BMIM][BF ]. The alkyl chains of the cations can fold and block interactions between the cations and anions, thereby reducing the cohesivity of the liquid. At room temperature, the folded conformations represent less than one-third of the total conformations.
View Article and Find Full Text PDFScandium(III) ions can form robust metal-organic frameworks (MOFs) with relative ease of synthesis. However, their use in MOF construction remains scarce compared to the vast collection of MOFs using other ions. This highlight features the chronological development of Sc(III)-MOFs, which attest to the ability of Sc(III) ions to afford materials that combine exceptional stability with catalytic or photo-physical attributes.
View Article and Find Full Text PDFNanoconfinement is a recent strategy to enhance solubility and dissolution of active pharmaceutical ingredients (APIs) with poor biopharmaceutical properties. In this work, we combine the advantage of cocrystals of racemic praziquantel (PZQ) containing a water-soluble coformer (i.e.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
November 2021
The mechanical stability of nanothin free-standing films made of melted polyethylene chains was predicted via molecular dynamics simulations in the range of 373.15-673.15 K.
View Article and Find Full Text PDFCarbohydr Polym
October 2021
A novel brush-like poly(2-aminoethyl methacrylate) (PAEMA) was grafted onto chitosan (CS) through gamma radiation-induced polymerization. The copolymer (CS-g-PAEMA) was used to prepare a sodium acetate leached poly(urethane-urea) scaffold. The above derivatives were developed, synthesized, and characterized to meet the specific characteristics of biomaterials.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2021
NOTT-401 was found to be a highly stable adsorbent for SO2 and CO with excellent cyclability and a straightforward regeneration at room temperature. Moreover, the preferential CO binding sites within the MOF material have been identified by experimental in situ DRIFT spectroscopy coupled with DFT and QTAIM calculations. Such preferential CO adsorption sites were correlated to identify the most significant SO2 interactions within NOTT-401.
View Article and Find Full Text PDFSulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal-organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine.
View Article and Find Full Text PDFThe Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).
View Article and Find Full Text PDFFunctionalized copolymers were synthesized and are proposed as hosts of RNA. The copolymers are based on carboxymethyl cellulose and poly-(ethylene glycol)-OH. These copolymers were functionalized with two amino acids, either lysine or histidine, through amide bond formation.
View Article and Find Full Text PDFBackground: Previous studies analyzed a series of representative anatomical regions in the human body; however, there is a wide structural and cellular variability in the constitution of the skin. Our objective was to perform a comprehensive assessment of human skin hydration throughout the largest possible area.
Materials And Methods: Hydration was registered by Corneometer CM825 probe in 23 anatomical regions of five healthy men.
We carried out molecular dynamics simulations of the liquid/vacuum equilibrium of the ionic liquid [bmim][triflate] in a wide range of temperatures (323.15 to 573.15 K).
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