Publications by authors named "Enrique Chimal Juarez"
Article Synopsis
- Asymptomatic Alzheimer's disease (AsymAD) is characterized by the presence of Alzheimer's-related brain pathology without cognitive decline, allowing researchers to study brain resilience mechanisms.
- The study of AsymAD brains revealed unique features like higher core plaque levels, more active microglia, and less tau aggregation compared to typical Alzheimer's brains.
- Key findings indicate that efficient actin-based motility in microglia and reduced tau seeding could help protect against the harmful effects of amyloid-beta, potentially slowing the progression of Alzheimer's disease.
Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha-synuclein protein. Developing effective vaccines against synucleinopathies is challenging due to the difficulty of stimulating an immune-specific response against alpha-synuclein without causing harmful autoimmune reactions, selectively targeting only pathological forms of alpha-synuclein. Previous attempts using linear peptides and epitopes without control of the antigen structure failed in clinical trials.
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