Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer.

Background: There are several studies that indicate that cancer development may be conditioned by the activation of some biological systems that involve the interaction of different biomolecules, such as adenosine and vascular endothelial growth factor. These biomolecules have been targeted of some drugs for treat of cancer; however, there is little information on the interaction of purine derivatives with adenosine and vascular endothelial growth factor receptor (VEGF-R1).

Objective: The aim of this research was to determine the possible interaction of purine (1: ) and their derivatives (2-31: ) with A, A-adenosine receptors, and VEGF-R1.

Consequences of the exposure to abuse in the family of origin among victims of intimate partner violence in Nicaragua.

Intimate partner violence (IPV) has serious consequences for women, and their vulnerability is increased if their experiences related to abuse occurred at an early age. This study examines the risk of experiencing stressful life events (SLE) during the lives of Nicaraguan victims of IPV in situations of extreme poverty according to their exposure to episodes of violence in their family of origin. In the study participated 136 women victims of IPV living in the marginal areas of the city of León (Nicaragua).

Homeless people in León (Nicaragua): Conceptualizing and measuring homelessness in a developing country.

Homelessness is a global phenomenon that affects groups in situations of poverty and social exclusion, in both developed and developing nations. However, the scientific literature on homeless people in developing countries is scant. This work shows the difficulties defining homelessness and examines the necessary criteria for who will be deemed a homeless person in a developing country.