Understanding Health Care Provider Burnout When Caring for Patients With Refractory Epilepsy in the United States.

Background And Objectives: Among health care providers (HCPs), neurologists have one of the highest rates of burnout in the United States, compromising the quality and accessibility of patient care. Patients with refractory epilepsy are especially challenging to treat. This study aims to understand the burnout level in neurologists treating patients with refractory epilepsy and identify key contributing factors.

A dual-action antibiotic that kills vegetative cells and inhibits spore germination.

infection (CDI) is the most lethal of the five CDC urgent public health treats, resulting in 12,800 annual deaths in the United States alone [ (2019), www.cdc.gov/DrugResistance/Biggest-Threats.

Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target .

is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. is difficult to eradicate due to its ability to form spores, which are not susceptible to antibiotics.

Discovery of a Potent Picolinamide Antibacterial Active against .

A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. is a Gram-positive bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibiotic-impervious spores results in chronic disruption of normal gut flora and debilitating diarrhea and intestinal infection.

Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant .

β-Lactams are used routinely to treat infections. However, the emergence of methicillin-resistant (MRSA) renders them clinically precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin (a penicillin member of the β-lactams) against MRSA.

Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant (MRSA).

Methicillin-resistant (MRSA) is a global public health threat. MRSA has evolved a complex set of biochemical processes that mobilize the organism for inducible resistance on challenge by β-lactam antibiotics. Interfering pharmacologically with this machinery has the potential to reverse the β-lactam-resistance phenotype, whereby susceptibility to obsolete antibiotics would be restored.

Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.

Lytic transglycosylases (LTs) catalyze the non-hydrolytic cleavage of the bacterial cell wall by an intramolecular transacetalization reaction. This reaction is critically and broadly important in modifications of the bacterial cell wall in the course of its biosynthesis, recycling, manifestation of virulence, insertion of structural entities such as the flagellum and the pili, among others. The first QM/MM analysis of the mechanism of reaction of an LT, that for the Escherichia coli MltE, is undertaken.