The pathways and the mechanisms by which enters the brain.

Generally, initially infects the respiratory tract, but can spread, eventually crossing the blood-brain barrier (BBB) and causing meningitis or meningoencephalitis. Specifically, invades the vascular endothelial cells of the BBB, from which it enters the brain. The main mechanisms through which crosses the BBB are transcellular traversal, the paracellular pathway, and via Trojan horse.

Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study.

Background: High-flow nasal cannula (HFNC) oxygen therapy is essentially a constant-flow, noninvasive respiratory support system similar to a noninvasive ventilator operating in constant-flow mode. The clinical outcome of HFNC oxygen therapy is strongly associated with the pressure generated by high-flow gas and the patient's comfort level. This study was performed to explore the relevant factors affecting pressure and comfort of HFNC oxygen therapy in vivo.

Cardiac angiosarcoma with multiple pulmonary metastases: A case report and literature review.

In this report, we describe a 42-year-old man with dyspnea and recurrent hemoptysis who was diagnosed with cardiac angiosarcoma and multiple pulmonary metastases. Before visiting our hospital, he had been misdiagnosed with a lung infection. Bronchoscopy, multiple imaging methods, and extensive laboratory studies failed to identify a clear etiology.