In vitro effects and mechanisms of action of in .

Background And Aim: African trypanosomiasis poses serious health and economic concerns to humans and livestock in several sub-Saharan African countries. The aim of the present study was to identify the antitrypanosomal compounds from (whole plant) through a bioactivity-guided isolation and investigate the effects and mechanisms of action against ().

Experimental Procedure: Crude extracts and fractions were prepared from air-dried pulverized plant material of using the modified Kupchan method of solvent partitioning.

Paenidigyamycin A, Potent Antiparasitic Imidazole Alkaloid from the Ghanaian sp. DE2SH.

A new alkaloid paenidigyamycin A () was obtained from the novel Ghanaian sp. isolated from the mangrove rhizosphere soils of the tree growing in the wetlands of the Digya National Park, Ghana. Compound was isolated on HPLC at t = 37.