Publications by authors named "Enno Ci Veerman"
A dysbiotic state is believed to be a key factor in the onset of oral disease. Although oral diseases have been studied for decades, our understanding of oral health, the boundaries of a healthy oral ecosystem and ecological shift toward dysbiosis is still limited. Here, we present the ecobiological heterogeneity of the salivary ecosystem and relations between the salivary microbiome, salivary metabolome and host-related biochemical salivary parameters in 268 healthy adults after overnight fasting.
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- Saliva can influence the complement system after mucosal damage by activating or inhibiting the lectin pathway, depending on its components like salivary agglutinin (SAG).
- Surface-adsorbed saliva activates this pathway in certain individuals (secretors), while saliva in solution tends to inhibit it regardless of secretor status.
- The study emphasizes that the presence and state of SAG are crucial in determining whether saliva activates or inhibits the complement system's lectin pathway.
Aim: The aim of this study was to evaluate the rheological properties of saliva after submandibular botulinum toxin type A (BoNT-A) injections.
Method: We enrolled 15 children (11 males and six females; age range 3-17 y, mean age 9 y 10 mo) diagnosed with spastic (n=9) or dyskinetic (n=6) quadriplegic cerebral palsy (CP); Gross Motor Function Classification System level IV or V; and two children with intellectual disability (IQ<70) who experienced moderate to severe drooling. Salivary flow rate and drooling quotient were measured at baseline and at different times after BoNT-A injections up to 24 weeks.