Method development for the clearance study of the Pluronic F-68 nonionic surfactant used in the upstream process of monoclonal antibody production.

Pluronic F-68 is a nonionic surfactant, which is often used in the upstream process of biopharmaceutical production. However, the number of analytical methods developed for determination of Pluronic F-68 in the in-process and drug substance samples of biological drug production process is quite low. The lack of chromophore groups on the molecule and the interference caused by the high protein content of the samples hamper analysis.

Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase.

New derivatives of d-xylose with aglycons of the most efficient glucose derived inhibitors of glycogen phosphorylase were synthesized to explore the specificity of the enzyme towards the structure of the sugar part of the molecules. Thus, 2-(β-d-xylopyranosyl)benzimidazole and 3-substituted-5-(β-d-xylopyranosyl)-1,2,4-triazoles were obtained in multistep procedures from O-perbenzoylated β-d-xylopyranosyl cyanide. Cycloadditions of nitrile-oxides and O-peracetylated exo-xylal obtained from the corresponding β-d-xylopyranosyl cyanide furnished xylopyranosylidene-spiro-isoxazoline derivatives.

Prevalence and psychosocial background of anxiety and depression emerging during the first trimester of pregnancy: data from a Hungarian population-based sample.

Background: There are few surveys of antenatal depression and anxiety in Eastern-European countries. The aim of the present study was to gather prevalence data from a Hungarian sample and to search for associations between antenatal depression/anxiety and some psycho-social variables.

Subjects And Methods: A population-based monitoring system was created, covering every pregnant woman in the town of Szombathely, Western-Hungary for symptoms of depression and anxiety during the first trimester of pregnancy.

Synthesis of substituted 2-(β-D-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase.

Microwave assisted condensation of O-perbenzoylated C-(β-d-glucopyranosyl)formic acid with 1,2-diaminobenzenes in the presence of triphenylphosphite gave the corresponding O-protected 2-(β-d-glucopyranosyl)-benzimidazoles in moderate yields. O-Perbenzoylated C-(β-d-glucopyranosyl)formamide and -thioformamide were transformed into the corresponding ethyl C-(β-d-glucopyranosyl)formimidate and -thioformimidate, respectively, by Et3O·BF4. Treatment of the formimidate with 1,2-diaminobenzenes afforded O-protected 2-(β-d-glucopyranosyl)-benzimidazoles in good to excellent yields.

Association between health beliefs and health behavior in early pregnancy.

Folate-supplementation significantly reduces the risk of neural tube defects. The aim of this research was to reveal associations between health beliefs and folate -supplementation as well as other elements of health behavior among Hungarian women early in their pregnancy. Three-hundred and seven women in early pregnancy completed the second part of Health and Illness Scale.

Effects of depression, anxiety, self-esteem, and health behaviour on neonatal outcomes in a population-based Hungarian sample.

Objective: To investigate possible associations of maternal antenatal depression, anxiety and self-esteem with negative neonatal outcomes controlling for the effects of demographic covariates and health behaviour in a Hungarian sample.

Study Design: A population-based monitoring system was established in 10 districts of health visitors in Szombathely, Hungary, covering every woman registered as pregnant between February 1, 2008 and February 1 2009. Three hundred and seven expectant women in the early stage of their pregnancy were surveyed using the Short Form of Beck Depression Inventory for the measurement of depression and the Spielberger Trait-Anxiety Inventory for the measurement of anxiety.

[Effect of demographic factors on folate-supplementation and health-behavior of pregnant women].

Unlabelled: The aim was to scrutinize associations between folate-supplementation and other elements of health-behavior and demographic factors in pregnant women.

Methods: A population-based monitoring system was established in 10 districts of health visitors in Szombathely, Hungary. The system covered every woman registered as pregnant between 1st February 2008 and 1st February 2009.