Publications by authors named "Eniko Palko"
Cholesteatoma is an epidermal cyst with still unknown pathomechanism. The aim of the current study was to investigate molecular differences in the background of the hyperproliferative property and aggressive behavior typical of the cholesteatoma epithelium. The expression of three cytokeratin genes (KRT1, KRT10 and KRT19), the matrix metalloproteinase 9 gene (MMP9) and the tumor suppressor TP53 gene was measured by qRT-PCR in surgical samples of pediatric and adult cholesteatoma cases and their expression level was compared to that of normal skin samples from the retroauricular region of control individuals.
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- Cholesteatoma is a type of epidermoid cyst commonly found in the middle ear, characterized by hyperproliferative epithelium similar to skin cysts.
- The study investigates the expression of the c-MYC gene, known for its role in cell growth, in 26 cholesteatoma samples, 15 skin cysts (atheromas), and 5 normal skin samples.
- Results show that c-MYC expression is significantly higher in cholesteatoma compared to atheromas and normal skin, indicating a more aggressive growth pattern, with no notable difference between children and adults.