-derived acetate activates the hepatic AMPK/SIRT1/PGC-1 axis to alleviate ferroptosis in metabolic-associated fatty liver disease.

Emerging evidences have indicated the role of ferroptosis in the progression of metabolic-associated fatty liver disease (MAFLD); thus, inhibiting ferroptosis is a promising strategy for the development of MAFLD therapeutics. Recent studies have demonstrated the antioxidative effect of the gut commensal bacterium (); however, whether it can alleviate ferroptosis remains unclear. The current study indicates intervention efficiently reversed high-fat high-fructose diet (HFHFD)-induced lipid peroxidation and ferroptosis in the liver.

In Situ Ring Opening Polymerization of High-Performance Full-Color CsPbX@PDMS (X = Cl, Br, I) Nanospheres Toward Wide-Color-Gamut Displays.

Optimizing the three-primary-color perovskite quantum dots (TPC PQDs) is crucial for achieving ultra-wide color gamut displays. Although encapsulation is an effective strategy to improve the stability and optical performance of the TPC PQDs, the chemicals or environment employed in the coating procedure may attack the CsPbX PQDs and generate defects, damage, and ligand loss. Herein, a mild, facile and universal hexamethylcyclotrisiloxane (D3) in situ ring opening polymerization strategy is successfully developed for efficiently synthesizing high-brightness and extremely stable TPC CsPbX@PDMS (X = Cl, Br, I) nanospheres, with particularly friendlyness for fragile red and blue.

Combination chemotherapy with sintilimab for treatment of a male patient with primary pulmonary choriocarcinoma: a case report and literature review.

Primary pulmonary choriocarcinoma (PPC) is an extremely rare malignant cancer in men with no clinical guidelines for the treatment. Cytotoxic chemotherapy has a limited effect on the prognosis of PPC. Recently, immune checkpoint inhibitors (ICIs) have shown promising treatment effectiveness.

Tandem achromatic metasurface for waveguide coupling in full-color AR displays.

Waveguide coupling design is one of the most challenging topics in augmented reality (AR) near-eye displays (NED). The primary challenge stems from the necessity to simultaneously address two competing factors: the overall volume of the AR system and the occurrence of chromatic aberration. To address this issue, what we believe to be a novel tandem trilayer achromatic metasurface is specifically designed for waveguide coupling in AR NEDs, capable of achieving an achromatic effect in a nanometer-thin layer.

Umbilical cord-derived mesenchymal stromal cells: Promising therapy for heart failure.

Heart failure (HF) is a complex syndrome characterized by the reduced capacity of the heart to adequately fill or eject blood. Currently, HF remains a leading cause of morbidity and mortality worldwide, imposing a substantial burden on global healthcare systems. Recent advancements have highlighted the therapeutic potential of mesenchymal stromal cells (MSCs) in managing HF.

Neuron-inspired CsPbBr/PDMS nanospheres for multi-dimensional sensing and interactive displays.

Multifunctional materials have attracted tremendous attention in intelligent and interactive devices. However, achieving multi-dimensional sensing capabilities with the same perovskite quantum dot (PQD) material is still in its infancy, with some considering it currently challenging and even unattainable. Drawing inspiration from neurons, a novel multifunctional CsPbBr/PDMS nanosphere is devised to sense humidity, temperature, and pressure simultaneously with unique interactive responses.

Color-conversion displays: current status and future outlook.

The growing focus on enhancing color quality in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) has spurred significant advancements in color-conversion materials. Furthermore, color conversion is also important for the development and commercialization of Micro-LEDs. This article provides a comprehensive review of different types of color conversion methods as well as different types of color conversion materials.

Bioinspired Three-Mode Photosensitive Synaptic LED for Optical Information Processing.

Inspired by human sense organs, AI is advancing toward multimodal perception, with display technology evolving into intelligent human-computer interaction tools. However, hardware networks with multimodal responses connected by different devices bring problems such as delayed information transfer and inefficiency. Thus, an innovative three-mode photosensitive synaptic LED (PSSL) is first proposed by adding a photosensitive layer indacenodithiophene-benzothiadiazole (IDTBT) to the quantum-dot light-emitting diode (QLED), switched by changing the bias voltage.

Tandem light-emitting technology accelerates the commercial application of perovskite LEDs.

Hybrid tandem perovskite-organic LED has been developed to achieve high external quantum efficiency, narrow linewidth, and extended device lifespan, which shows great promise for future perovskite-EL-based commercial applications.

H-marker via bronchoscopy under LungPro navigation combined with cone-beam computed tomography for locating multiple pulmonary ground-glass nodules: A case report and literature review.

Rationale: Pulmonary ground-glass nodules (GGNs) pose challenges in intraoperative localization due to their primarily nonsolid composition. This report highlights a novel approach using H-marker deployment guided by LungPro navigation combined with cone-beam computed tomography (CBCT) for precise localization of multiple GGNs.

Patient Concerns: A 55-year-old female patient presented at Sir-Run-Run-Shaw Hospital, Zhejiang University School of Medicine, in June 2021, requiring thoracoscopic surgery for the management of multiple GGNs in her right lung.

Safety and efficacy of a novel transbronchial radiofrequency ablation system for lung tumours: One year follow-up from the first multi-centre large-scale clinical trial (BRONC-RFII).

Background And Objective: Radiofrequency ablation (RFA) is an emerging treatment of lung cancer, yet it is accompanied by certain safety concerns and operational limitations. This first multi-centre, large-scale clinical trial aimed to investigate the technical performance, efficacy and safety of an innovative transbronchial RFA system for lung tumours.

Methods: The study enrolled patients with malignant lung tumours who underwent transbronchial RFA using an automatic saline microperfusion system between January 2021 and December 2021 across 16 medical centres.

Anti-Helicobacter pylori Infection Treatment and Pulmonary Hypersensitivity: Case Series and Review of the Literature.

Background: Helicobacter pylori (H. pylori) infection is currently widespread throughout the world. Bismuth-containing quadruple therapy is widely used, but it has rarely been associated with interstitial lung disease.

Perovskite-Doped Modulated Color-Selective Photosynaptic Transistors for Target Object Recognition.

The processing of multicolor noisy images in visual neuromorphic devices requires selective absorption at specific wavelengths; however, it is difficult to achieve this because the spectral absorption range of the device is affected by the type of material. Surprisingly, the absorption range of perovskite materials can be adjusted by doping. Herein, a CdCl co-doped CsPbBr nanocrystal-based photosensitive synaptic transistor (PST) is reported.

Displacement Sensing for Laser Self-Mixing Interferometry by Amplitude Modulation and Integral Reconstruction.

To robustly and adaptively reconstruct displacement, we propose the amplitude modulation integral reconstruction method (AM-IRM) for displacement sensing in a self-mixing interferometry (SMI) system. By algebraically multiplying the SMI signal with a high-frequency sinusoidal carrier, the frequency spectrum of the signal is shifted to that of the carrier. This operation overcomes the issue of frequency blurring in low-frequency signals associated with continuous wavelet transform (CWT), enabling the precise extraction of the Doppler frequency of the SMI signal.

Broadband beam collimation metasurface for full-color micro-LED displays.

Near-eye displays are widely recognized as a groundbreaking technological advancement with the potential to significantly impact daily life. Within the realm of near-eye displays, micro-LEDs have emerged as a highly promising technology owing to their exceptional optical performance, compact form factor, and low power consumption. However, a notable challenge in integrating micro-LEDs into near-eye displays is the efficient light collimation across a wide spectrum range.

Wemics: A Single-Base Resolution Methylation Quantification Method for Enhanced Prediction of Epigenetic Regulation.

DNA methylation, an epigenetic mechanism that alters gene expression without changing DNA sequence, is essential for organism development and key biological processes like genomic imprinting and X-chromosome inactivation. Despite tremendous efforts in DNA methylation research, accurate quantification of cytosine methylation remains a challenge. Here, a single-base methylation quantification approach is introduced by weighting methylation of consecutive CpG sites (Wemics) in genomic regions.

Virtual bronchoscopic navigation with intraoperative cone-beam CT for the diagnosis of peripheral pulmonary nodules.

Objective: Transbronchial biopsy is a safe manner with fewer complications than percutaneous transthoracic needle biopsy; however, the current diagnostic yield is still necessitating further improvement. We aimed to evaluate the diagnostic yield of using virtual bronchoscopic navigation (VBN) and cone-beam CT (CBCT) for transbronchial biopsy and to investigate the factors that affected the diagnostic sensitivity.

Methods: We retrospectively investigated 255 patients who underwent VBN-CBCT-guided transbronchial biopsy at our two centers from May 2021 to April 2022.

Effect of polymethyl methacrylate on in situ patterning of perovskite quantum dots by inkjet printing.

The preparation of perovskite quantum dots (PQDs) using an in situ inkjet printing method is beneficial for improving the problems of aggregation and photoluminescence (PL) quenching during long-term storage. However, the stability of PQDs prepared using this method is still not ideal, and the morphology of in situ-printed patterns needs to be optimized. To address these problems, this study introduced polymethyl methacrylate (PMMA) into the process of in situ inkjet printing of PQDs and explored the effect of PMMA on the in situ patterning effect of PQDs.

Chinese expert consensus on cone-beam CT-guided diagnosis, localization and treatment for pulmonary nodules.

Cone-beam computed tomography (CBCT) system can provide real-time 3D images and fluoroscopy images of the region of interest during the operation. Some systems can even offer augmented fluoroscopy and puncture guidance. The use of CBCT for interventional pulmonary procedures has grown significantly in recent years, and numerous clinical studies have confirmed the technology's efficacy and safety in the diagnosis, localization, and treatment of pulmonary nodules.

Uniformity improvement of a mini-LED backlight by a quantum-dot color conversion film with nonuniform thickness.

Mini-LED backlights energized by quantum-dot color conversion (QDCC) hold great potential for technological breakthroughs of liquid crystal displays. However, luminance uniformity issues should still be urgently solved owing to the large interval of direct-lit mini-LEDs, especially when covering with a QDCC film (QDCCF) with uniform thickness. Herein, we propose a uniformity improvement approach of mini-LED backlights by employing a QDCCF with nonuniform thickness based on the Lambertian distribution of mini-LEDs, which is demonstrated by screen-printing preparation and ray-tracing simulation.

Development and validation of a risk-prediction model for immune-related adverse events in patients with non-small-cell lung cancer receiving PD-1/PD-L1 inhibitors.

Lung cancer remains the leading cause of cancer deaths worldwide and is the most common cancer in males. Immune-checkpoint inhibitors (ICIs) that target programmed cell death protein-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) have achieved impressive efficacy in the treatment of non-small-cell lung cancer (NSCLC) (Pardoll, 2012; Champiat et al., 2016; Gao et al.