A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidine ribose sulfamate, ML901, as a potent reaction hijacking inhibitor of PfTyrRS. Here we examined the stage specificity of action of ML901, showing very good activity against the schizont stage, but lower trophozoite stage activity.

Gain-Induced Group Delay in Spontaneous Parametric Down-Conversion.

Strongly driven nonlinear optical processes such as spontaneous parametric down-conversion and spontaneous four-wave mixing can produce multiphoton nonclassical beams of light which have applications in quantum information processing and sensing. In contrast to the low-gain regime, new physical effects arise in a high-gain regime due to the interactions between the nonclassical light and the strong pump driving the nonlinear process. Here, we describe and experimentally observe a gain-induced group delay between the multiphoton pulses generated in a high-gain type-II spontaneous parametric down-conversion source.

Programmable Photonic Quantum Circuits with Ultrafast Time-Bin Encoding.

We propose a quantum information processing platform that utilizes the ultrafast time-bin encoding of photons. This approach offers a pathway to scalability by leveraging the inherent phase stability of collinear temporal interferometric networks at the femtosecond-to-picosecond timescale. The proposed architecture encodes information in ultrafast temporal bins processed using optically induced nonlinearities and birefringent materials while keeping photons in a single spatial mode.

Use of cardiac gated computed tomography in the diagnosis of a rare congenital cardiovascular anomaly in an adult alpaca.

A 5-year-old female alpaca was presented with respiratory distress and lethargy. Thoracic radiographs revealed a cranioventrally distributed alveolar pattern, caudodorsal bronchial pattern, cardiomegaly, increased soft tissue opaque content in the ventral thorax, and rounded soft tissue opaque structures craniodorsal to the carina. Cardiac gated CT demonstrated a patent ductus arteriosus, ventricular septal defect, complete left atrioventricular valve atresia, partial anomalous venous connections from the cranial pulmonary veins to the azygous and cranial vena cava, severe right-sided cardiomegaly, pleural and peritoneal fluid, and severe hepatic congestion.

The long shadow of accumulating adverse childhood experiences on mental health in the United Arab Emirates: implications for policy and practice.

Introduction: This study investigates the cumulative effects of adverse childhood experiences (ACEs) on adult depression, anxiety, and stress in Abu Dhabi, controlling for demographic factors, lifestyle, and known health and mental health diagnoses.

Methods: Utilizing a cross-sectional design and self-report measures, the research aims to fill a critical gap in understanding the specific impacts of ACEs in the UAE. Based on a multi-site, cross-sectional community sample of 697 residents of Abu Dhabi.

Functional and perceptive differences between conventional and advanced ankle foot orthoses in community ambulators post-limb trauma: the injuries managed with advanced bracing of the lower extremity (IM ABLE) study.

Introduction: Many military service members and civilians suffer from lower extremity trauma. Despite recent advancements in lower limb bracing technology, it remains unclear whether these newer advanced braces offer improved comfort and functionality compared to conventional options. The IDEO (Intrepid Dynamic Exoskeletal Orthosis), a type of "advanced" orthosis was developed to assist in maintaining high functional performance in patients who have experienced high-energy lower extremity trauma and underwent limb salvage surgeries.

The gendered behaviors displayed by Disney protagonists.

Previous research suggests that the portrayal of male and female protagonists in Disney animations may be changing over time. The current study examined the portrayal of gendered behaviors displayed within some of Disney's most successful animated feature length films, including those beyond the Disney princess franchise. Extending the scope of the Disney animated films analyzed was important because both young girls and young boys report little personal interest in male characters within the Disney princess animations.

Patterns of Gender Development Across Intersections of Age, Gender, and Ethnicity-Race.

Two components of gender identity are gender similarity, how one's self-concept relates to the major gender collectives (i.e., female, male), and felt pressure to conform to gender norms.

Intensity correlation holography for remote phase sensing and 3D imaging.

Holography is an established technique for measuring the wavefront of optical signals through interferometric combination with a reference wave. Conventionally the integration time of a hologram is limited by the interferometer coherence time, thus making it challenging to prepare holograms of remote objects, especially using weak illumination. Here, we circumvent this limitation by using intensity correlation interferometry.

Intensity interferometry for holography with quantum and classical light.

As first demonstrated by Hanbury Brown and Twiss, it is possible to observe interference between independent light sources by measuring correlations in their intensities rather than their amplitudes. In this work, we apply this concept of intensity interferometry to holography. We combine a signal beam with a reference and measure their intensity cross-correlations using a time-tagging single-photon camera.

Activity and Participation, Bimanual Function, and Prosthesis Satisfaction are Strong Predictors of General Well-Being Among Upper Limb Prosthesis Users.

Objective: To determine the role of multiple factors on general well-being for upper limb prosthesis users.

Design: Retrospective cross-sectional observational design.

Setting: Prosthetic clinics across the United States.

Creating Adjusted Scores Targeting mobiLity Empowerment (CASTLE 1): determination of normative mobility scores after lower limb amputation for each year of adulthood.

Purpose: As United States healthcare transitions from traditional fee-for-service models to value-based care, there is increased need to demonstrate quality care through clinical outcomes. Therefore, the purpose of this study was to create equations to calculate an expected mobility score for lower limb prosthesis users specific to their age, etiology, and amputation level to provide benchmarks to qualify good outcomes.

Materials And Methods: A retrospective cross-sectional analysis of outcomes collected during clinical care was performed.

GGEM: Gender, Geography, and EMployment differences based on mobility levels among lower limb prosthesis users living in the United States.

Background: For individuals with a disability, an increase in functional mobility may improve their quality of life and well-being. Greater understanding is needed on how factors such as gender, geography, and employment may play a role in mobility levels among individuals with lower limb amputation.

Objectives: To assess the relationship between gender, geography, and employment status on mobility among lower limb prosthesis users.

Snapshot hyperspectral imaging with quantum correlated photons.

Hyperspectral imaging (HSI) has a wide range of applications from environmental monitoring to biotechnology. Conventional snapshot HSI techniques generally require a trade-off between spatial and spectral resolution and are thus limited in their ability to achieve high resolutions in both simultaneously. Most techniques are also resource inefficient with most of the photons lost through spectral filtering.

Characterisation of a single photon event camera for quantum imaging.

We show a simple yet effective method that can be used to characterize the per pixel quantum efficiency and temporal resolution of a single photon event camera for quantum imaging applications. Utilizing photon pairs generated through spontaneous parametric down-conversion, the detection efficiency of each pixel, and the temporal resolution of the system, are extracted through coincidence measurements. We use this method to evaluate the TPX3CAM, with appended image intensifier, and measure an average efficiency of [Formula: see text]% and a temporal resolution of 7.

Ultratunable Quantum Frequency Conversion in Photonic Crystal Fiber.

Quantum frequency conversion of single photons between wavelength bands is a key enabler to realizing widespread quantum networks. We demonstrate the quantum frequency conversion of a heralded 1551 nm photon to any wavelength within an ultrabroad (1226-1408 nm) range in a group-velocity-symmetric photonic crystal fiber, covering over 150 independent frequency bins. The target wavelength is controlled by tuning only a single pump laser wavelength.

No effect of a dairy-based, high flavonoid pre-workout beverage on exercise-induced intestinal injury, permeability, and inflammation in recreational cyclists: A randomized controlled crossover trial.

Background: Submaximal endurance exercise has been shown to cause elevated gastrointestinal permeability, injury, and inflammation, which may negatively impact athletic performance and recovery. Preclinical and some clinical studies suggest that flavonoids, a class of plant secondary metabolites, may regulate intestinal permeability and reduce chronic low-grade inflammation. Consequently, the purpose of this study was to determine the effects of supplemental flavonoid intake on intestinal health and cycling performance.

Microprocessor feet improve prosthetic mobility and physical function relative to non-microprocessor feet.

The clinical benefits associated with the microprocessor regulation of prosthetic ankle position and resistance have largely been reported through manufacturer conducted research in controlled laboratory environments. Measures with greater ecological validity are needed. This study aimed to understand if there are differences in physical function and mobility outcomes as patients transitioned from a non-Microprocessor to Microprocessor Feet.

OASIS 2: Mobility differences with specific prosthetic feet across procedure codes.

Introduction: Recently, many prosthetic devices were subjected to reimbursement coding review. Several prosthetic feet that were historically coded with the shock-attenuating function were recoded. The purpose of this analysis was to compare patient-reported functional mobility across a range of prosthetic feet using real-world clinical outcomes data.

Toward a Quantum Memory in a Fiber Cavity Controlled by Intracavity Frequency Translation.

We propose a quantum memory protocol based on trapping photons in a fiber-integrated cavity, comprised of a birefringent fiber with dichroic reflective end facets. Photons are switched into resonance with the fiber cavity by intracavity Bragg-scattering frequency translation, driven by ancillary control pulses. After the storage delay, photons are switched out of resonance with the cavity, again by intracavity frequency translation.

Mobility Analysis of AmpuTees (MAAT 7): Normative Mobility Values for Lower Limb Prosthesis Users of Varying Age, Etiology, and Amputation Level.

Objective: The aim of the study was to establish normative values of lower limb amputation mobility across primary etiologies based on age and amputation level.

Design: This study is a cross-sectional observational analysis of outcomes. A total of 11,995 lower limb prosthesis users were included in the analysis.

High speed imaging of spectral-temporal correlations in Hong-Ou-Mandel interference.

In this work we demonstrate spectral-temporal correlation measurements of the Hong-Ou-Mandel (HOM) interference effect with the use of a spectrometer based on a photon-counting camera. This setup allows us to take, within seconds, spectral temporal correlation measurements on entangled photon sources with sub-nanometer spectral resolution and nanosecond timing resolution. Through post processing, we can observe the HOM behaviour for any number of spectral filters of any shape and width at any wavelength over the observable spectral range.

Exploring the reliability of the exposure index with a range of kV and mAs values: An experimental study.

Introduction: The exposure index (EI) is a numerical post-exposure tool that provides feedback to diagnostic radiographers undertaking digital X-ray examinations. The EI seeks to provide an indicator of the quantity of incident ionising radiation imparted on an image receptor. However, any large increase to X-ray intensity could interfere with the calculation of the EI.

A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models.

SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK-981, a selective small-molecule inhibitor of SUMOylation, pharmacologically reactivates IFN1 signaling and immune responses against cancers. In vivo treatment of wild-type mice with TAK-981 up-regulated IFN1 gene expression in blood cells and splenocytes.

Modified Cephalic Index Measured at Superior Levels of the Cranium Revealed Improved Correction With Helmet Therapy for Patients With Sagittal Suture Craniosynostosis.

Objective: Historically, studies have shown that cranial remolding therapy improves surgical correction and protects against regression for patients with sagittal suture craniosynostosis. This study aimed to define the most responsive cranial height for measuring cephalic index (CI) following cranial remolding therapy for infants with sagittal suture craniosynostosis.

Methods: The authors performed a retrospective analysis of data between January 2018 and August 2019.