Publications by authors named "Enes Karaman"
Boric Acid Protects the Uterus and Fallopian Tubes from Cyclophosphamide-Induced Toxicity in a Rat Model.
Pharmaceuticals (Basel)
December 2024
: Cyclophosphamide (CP) is widely used for treating various cancers and autoimmune diseases, but it causes damage to reproductive organs due to oxidative stress (OS) and inflammation. Boric acid (BA) has antioxidant properties that may help reduce OS, which is critical for preserving uterine functionality, particularly for cancer patients considering pregnancy after cryopreservation. This study aimed to determine whether BA could diminish CP-induced toxicity in the uterus and fallopian tubes (FT) using CP-induced toxicity in a rat model.
View Article and Find Full Text PDFNegative effects of ethanol on ovarian reserve and endometrium thickness: An animal study.
Turk J Obstet Gynecol
September 2024
Objective: This study aimed to assess the effect of ethanol on the ovarian reserve and endometrium of rats by evaluating anti-Müllerian hormone (AMH) levels and follicle counts.
Materials And Methods: We performed histological follicle counting and AMH measurements to evaluate ovarian reserve. The study included 16 Wistar albino rats evenly distributed into two groups of eight rats each.
Article Synopsis
- Ovarian ischemia, often caused by ovarian torsion, is a critical condition impacting women of reproductive age, leading to decreased ovarian reserve; this study explores the effects of boric acid treatment on ovarian damage in female rats during ischemia/reperfusion.* -
- Researchers created seven groups of rats, applying different methods of boric acid administration to assess its impact on histopathological changes, oxidative stress, and DNA integrity after ovarian ischemia and subsequent reperfusion.* -
- Results showed that boric acid significantly mitigated inflammation and preserved ovarian follicle structure, improved biochemical markers like AMH, and reduced oxidative stress and DNA damage, indicating its potential therapeutic effects on ovarian ischemia injuries.*
Article Synopsis
- - This study investigates the protective effects of boric acid on female rat oocytes exposed to nonylphenol (NP), highlighting its potential in preserving ovarian quality and function.
- - Histopathological and biochemical analyses revealed that boric acid mitigated tissue damage, restored hormone levels, and provided DNA protection, suggesting its positive impact on ovarian health.
- - The findings indicate that boric acid may effectively counteract the negative effects of NP, reducing oxidative stress and inflammation, and thus plays a protective role against infertility caused by NP exposure.
Article Synopsis
- The study aimed to assess the effects of hyperbaric oxygen therapy (HBO) on ovarian health in a rat model of ovarian insufficiency induced by cyclophosphamide (CYP).
- The research involved three rat groups: control, CYP, and CYP+HBO, with significant changes in follicle counts and hormone levels observed after treatment.
- Results indicated that HBO therapy could help counteract the ovarian damage caused by CYP, potentially offering a new treatment for young females facing ovarian follicle loss during chemotherapy.