Publications by authors named "Endeshaw C Abebe"

Objective: Globally, skull base tumors are among the most challenging tumors to treat and are known for their significant morbidity and mortality. Hence, this study aimed to identify robust associated factors that contribute to mortality of patients following surgical resection for a variety of skull base tumors at the 3-month follow-up period. This in turn helps devise an evidence-based meticulous treatment strategy and baseline input for quality improvement work.

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Background: Children with cerebral palsy face various challenges, including oral hygiene, which is crucial for their overall well-being and quality of life. However, limited research investigates oral hygiene among children with cerebral palsy. This systematic review and meta-analysis aim to assess the proportion of good oral hygiene and mean value oral hygiene index among children with cerebral palsy in Africa and Asia.

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  • The study looked at how running at high altitudes affects athletes from two different sports clubs in Ethiopia, one at 2400 meters and the other at 3100 meters above sea level.
  • They compared things like oxygen levels, heart rate, and training habits among the runners and some people who don't run.
  • The results showed that the runners at the higher altitude club had lower oxygen levels but better maximum oxygen usage than the runners at the lower altitude club.
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  • Sub-Saharan Africa has the highest neonatal mortality rate in the world at 27/1000 live births, with a significant number of deaths occurring within the first week, particularly on the first day of life.
  • A comprehensive review was conducted, analyzing data from various databases to estimate early neonatal mortality rates, utilizing methods to assess study quality and statistical variation in findings.
  • The pooled data from 14 studies indicated an early neonatal mortality rate of 80.3 per 1000 live births in sub-Saharan Africa, with Ethiopia showing the highest rate of 20.1% and Cameroon the lowest at 0.5%, revealing considerable variation among the studies analyzed.
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Background: Immunization is one of the most cost-effective interventions, averting 3.5-5 million deaths every year worldwide. However, incomplete immunization remains a major public health concern, particularly in Ethiopia.

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Introduction: Sexual behaviour needs to take a central position in the heart of public health policy makers and researchers. This is important in view of its association with Sexually Transmitted Infections (STIs), including HIV. Though the prevalence of HIV/AIDS is declining in Ethiopia, the country is still one of the hardest hit in the continent of Africa.

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Background: Preeclampsia (PE), a pregnancy specific syndrome, is defined as new-onset hypertension (≥140/90 mmHg) and proteinuria diagnosed after gestational week 20 or new-onset pre-eclampsia associated signs in the absence of proteinuria, and it may tend to present as late as 4-6 weeks' postpartum period. It is a leading cause of maternal mortality in both developed and developing countries. In order to prevent PE, the disease must be diagnosed at its earliest stage, however, the triads of high blood pressure, edema and albuminuria is neither specific nor sensitive enough for diagnosing the disease.

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Introduction: Vaccination is the most cost-effective approach that significantly reduces morbidity and mortality related to Coronavirus disease -19 (COVID-19). Nevertheless, there is a lack of information on the COVID-19 vaccine uptake and related factors in Ethiopia including the research area.

Objective: To assess COVID-19 vaccine uptake and its associated factors among adult population in Dangila District, Awi Zone, Northwest Ethiopia, 2023.

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Malnutrition is more prevalent among children with cerebral palsy and a major factor for child morbidity and mortality in children with different co-morbidity, especially in Sub-Saharan Africa: The main aim of this systematic review and meta-analysis was to estimate the burden of malnutrition among children with cerebral palsy in Sub-Saharan Africa. We searched PubMed, Web of Science, Google Scholar, Research Gate, and institutional repositories for papers that reported the proportion of malnutrition among children with cerebral palsy that were published between December 2010 and September 2023. Data were retrieved using the standardized JBI data extraction checklist through Microsoft Excel, and then exported to STATA 17 for further analysis.

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  • * Conducted at Yikatit 12 Hospital Medical College in Ethiopia, the study involved 55 hypertensive patients with ischemic stroke and 110 without, using ROC curves to evaluate the diagnostic effectiveness of the biomarkers.
  • * Results indicated D-dimer had the highest diagnostic power (AUC = 0.776), followed by DDFR (AUC = 0.763) and fibrinogen (AUC = 0.694), suggesting these biomarkers could enhance
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  • - Nutritional status, specifically body mass index (BMI), is crucial for diagnosing and monitoring the health of HIV-positive adults undergoing antiretroviral therapy (ART), especially in low-income countries like Ethiopia.
  • - A study in Northwest Ethiopia analyzed BMI changes in 404 HIV-positive adults receiving ART and found that average BMI increased from 20.34 to 21.41, indicating overall health improvement.
  • - Factors affecting BMI change included the duration of ART, unemployment status, disease advancement (WHO stage III/IV), and the specific ART regimen used, highlighting the complexity of nutrition management in HIV treatment.
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Introduction: the majority of studies in Ethiopia determine the prevalence of glycemic control employed by fasting blood sugar (FBS), which is impacted by a variety of factors. Hence, the purpose of this study was to assess the status of glycemic control using HbA1c and its correlates in patients with type 2 diabetes in Southwest Ethiopia.

Methods: a cross-sectional study was employed among 124 T2 diabetes mellitus (DM) patients at Jimma Medical Center (JMC), Southwest Ethiopia.

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Introduction: One of the most prevalent causes of physical disability in children is cerebral palsy (CP), which is a series of complicated neurological disorders. Children with cerebral palsy suffer from multiple problems and potential disabilities, including dental caries. Hence, this study aimed to determine the pooled prevalence of dental caries and mean DMFT (Decayed, Missed, and Filled Permanent Teeth) among children with cerebral palsy in Africa and Asia.

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Background: Early posttraumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI) that can induce the development of secondary brain injuries, including increased intracranial pressure, brain death, and metabolic crisis which may result in worse outcomes. It is also a well-recognized risk factor for the development of late post-traumatic seizure and epilepsy. This study was aimed to assess the incidence and predictors of PTS among patients with moderate or severe TBI admitted to Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia.

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  • The CRISPR-Cas9 system is a powerful genome-editing tool that can help address various genetic disorders by precisely targeting and modifying DNA.
  • It consists of a single-guide RNA (sgRNA) that directs the Cas9 protein to specific DNA sequences, allowing for targeted editing.
  • A major concern with CRISPR-Cas9 is off-target effects, where unintended DNA modifications occur, which can undermine its effectiveness and reliability; this review discusses recent improvements aimed at minimizing these off-target effects.
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  • Neonatal tetanus remains a significant public health issue in Ethiopia, with low maternal tetanus toxoid vaccination rates contributing to unprotected births.
  • The study analyzed data from the 2016 Ethiopia Demographic and Health Survey, revealing that over 54% of births were unprotected, particularly in regions like Northeastern Tigray and the Somali region, where spatial clusters were identified.
  • Key factors associated with higher rates of tetanus-unprotected births included lack of formal education, poverty, absence of antenatal care (ANC), and limited media exposure, suggesting that targeted interventions should address these underlying issues in hotspot areas.
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  • Contraception is key for preventing unplanned pregnancies and reducing maternal deaths from unsafe abortions, highlighting the importance of promoting modern contraceptive methods.
  • A study conducted in Debre Tabor Town, Ethiopia, surveyed 423 housemaids to assess their knowledge, attitudes, and practices regarding contraception, revealing that only 12.8% used modern methods but 44.68% had good knowledge and 36.40% had positive attitudes.
  • Socio-demographic factors like age, urban living, education, and work experience positively influenced the housemaids’ understanding and acceptance of modern contraceptive methods, indicating a need for targeted education and resources from the health sector.
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Background: Early marriage is defined as the union of one or both partners before reaching the age of 18 for the first time. This practice is widely prevalent in underdeveloped countries, particularly in Ethiopia, and has been observed to have detrimental effects on the educational and personal development of both male and female individuals.

Methods: The present study conducted a comprehensive search of the Science Direct, Scopus, Google Scholar, EMBASE, and PubMed databases.

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Background: Anthropometry is a universally applicable, non-expensive, rapid and noninvasive technique used to evaluate and reflect the nutritional status of an individual. Anthropometric measurements of newborns reflect their general health, nutritional status and future survival by tracking trends in growth and development over time. It has also considerable significance in terms of determining the risk of death and extra uterine complications.

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  • * It found that hypertension prevalence varied by country, with the lowest rate in Ethiopia (16.13%) and the highest in Tanzania (26.76%).
  • * Factors significantly associated with hypertension included alcohol consumption, diabetes, longer duration of HIV, male sex, obesity, and older age.
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Background: Child marriage is a harmful traditional practice, which compromises children of their childhood and threatens their lives and health. In Ethiopia, 58% of women and 9% of men get married before the age of 18 years. Surprisingly, parents in the Amhara region make marriage promises of their children before they are even born, which will hinder the region from attaining the Sustainable Development Goal of ending child marriage.

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Background: Chronic kidney disease (CKD) is a non-communicable disease leading to a progressive decline in kidney functions and complications like liver disorders. Serum levels of liver parameters such as aminotransferases and bilirubin are important biomarkers for the diagnosis of liver diseases. Studies on the effect of CKD with and without end-stage renal disease (ESRD) on the levels of liver biomarkers in Ethiopia are limited.

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Background: Human Immunodeficiency Virus positive status disclosure is an essential component of pediatric care and longterm disease management. However, one of the greatest challenges that caregiver/mothers and health care workers face is the disclosure of HIV positive status to children living with the virus. Therefore, the objective of this study was to assess HIV positive status disclosure and associated factors among HIV positive children in northwest Ethiopia.

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  • Malaria during pregnancy poses serious risks to mothers and babies, and insecticide-treated nets (ITNs) are recommended for prevention.
  • A systematic review of studies in Ethiopia found that only 59.42% of pregnant women utilized ITNs, indicating a significant gap from national targets.
  • Factors such as higher education, antenatal care attendance, and knowledge of malaria prevention significantly increased the likelihood of ITN usage among pregnant women.
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Background: Globally, the co-occurrence of stunting and overweight or obesity (CSO) in the same individual is becoming an emerging layer of malnutrition and there is a paucity of information in low- and middle-income countries, particularly in sub-Saharan Africa. Hence, this study aimed to determine the pooled prevalence and determinants of concurrent stunting and overweight or obesity among under-five children in SSA.

Methods: Secondary data analysis was conducted from a recent nationally representative Demographic and Health Survey dataset of 35 SSA countries.

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