Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African and Species (Combretaceae): A Review.

Bacterial and fungal resistance to antibiotics is of growing global concern. Plants such as the African and species, which are used in traditional medicine for the treatment of infections, could be good sources for antimicrobial extracts, drug scaffolds, and/or antibiotic adjuvants. In African countries, plant species are often used in combinations as traditional remedies.

Anti- Activity of Extracts Containing Ellagitannins, Triterpenes and Flavonoids of , a Medicinal Plant Growing in Semi-Arid and Savannah Woodland in Sudan.

Various parts of Terminalia brownii (Fresen) are used in Sudanese traditional medicine against fungal infections. The present study aimed to verify these uses by investigating the anti-Candida activity and phytochemistry of T. brownii extracts.

Hydrolyzable tannins (ellagitannins), flavonoids, pentacyclic triterpenes and their glycosides in antimycobacterial extracts of the ethnopharmacologically selected Sudanese medicinal plant Combretum hartmannianum Schweinf.

In Sudanese traditional medicine, decoctions, macerations, and tonics of the stem and root of Combretum hartmannianum are used for the treatment of persistent cough, a symptom that could be related to tuberculosis (TB). To verify these traditional uses, extracts from the stem wood, stem bark, and roots of C. hartmannianum were screened for their growth inhibitory effects against Mycobacterium smegmatis ATCC 14468.

HPLC-DAD and UHPLC/QTOF-MS Analysis of Polyphenols in Extracts of the African Species , and Related to Their Antimycobacterial Activity.

Engl. & Diels, Welv. and Sond.

Potential Anti-Tuberculosis Activity of the Extracts and Their Active Components of (DC.) Guill. and Perr. with Special Emphasis on Polyphenols.

In Sudanese traditional medicine, decoctions of the stem bark of are used for the treatment of tuberculosis (TB). However, this plant has not been investigated before for its antimycobacterial effects. Our screening results show, for the first time, that many extracts of various parts of exhibit growth inhibitory activity against .

Terminalia laxiflora and Terminalia brownii contain a broad spectrum of antimycobacterial compounds including ellagitannins, ellagic acid derivatives, triterpenes, fatty acids and fatty alcohols.

Ethnopharmacological Relevance: Terminalia laxiflora Engl. & Diels, (Sudanese Arabic name: Darout الدروت) and Terminalia brownii Fresen (Sudanese Arabic name: Alshaf ألشاف) (Combretaceae) are used in Sudanese traditional folk medicine and in other African countries for treatment of infectious diseases, TB and its symptoms, such as cough, bronchitis and chest pain.

Aim Of Study: Because of the frequent use of T.

LC-MS/MS Tandem Mass Spectrometry for Analysis of Phenolic Compounds and Pentacyclic Triterpenes in Antifungal Extracts of Terminalia brownii (Fresen).

Decoctions and macerations of the stem bark and wood of Fresen. are used in traditional medicine for fungal infections and as fungicides on field crops and in traditional granaries in Sudan. In addition, water extracts are commonly used as sprays for protecting wooden houses and furniture.