Publications by authors named "Enas Hallumi"
Article Synopsis
- The costimulatory receptor CD28 works alongside the T cell receptor (TCR) to enhance IL-2 production, cell survival, and proliferation, but the exact relationship between their signaling pathways is not fully understood.
- Researchers discovered that TCR stimulation activates a signaling complex involving adaptors Gads, LAT, and SLP-76, where the phosphorylation of specific sites by the Tec-family kinase Itk plays a critical role.
- The study reveals that phosphorylation of Gads at Y45 is crucial for promoting IL-2 transcription through TCR/CD28 signaling, suggesting a new regulatory mechanism that underscores the interdependence of TCR and CD28 pathways in T cell activation.
Article Synopsis
- The T cell receptor (TCR) signaling pathway relies on various proteins for a functional immune response, and any disruption can lead to severe immunodeficiency.
- A case study presents an infant with severe immunodeficiency due to novel biallelic mutations in the SLP76 gene, which is vital for TCR signaling and hematopoietic functions.
- The research links SLP76 deficiency to life-threatening infections and immunodeficiencies, while also modeling the patient’s immune issues in a lab setting to better understand the disease and its effects.
Sci Signal
September 2017
Article Synopsis
- The assembly of signalosomes, crucial for T cell and mast cell signaling, requires the adaptor protein LAT, which interacts with cytosolic proteins from the Grb2 family.
- Research revealed that the protein Gads from the Grb2 family can dimerize via a specific SH2 domain interface, enhancing its binding to LAT molecules that are fully phosphorylated.
- Mutations that disrupt this dimerization reduce Gads' cooperativity and effectiveness in signaling, suggesting that proper Gads-LAT interaction boosts the cell's sensitivity to antigens by optimizing signalosome formation.
