Publications by authors named "Enas Dammag"
Bilateral Sudden Irreversible Hearing Loss in a Case of Chronic Myeloid Leukaemia: A Case Report.
Indian J Otolaryngol Head Neck Surg
April 2024
Chronic myeloid leukemia is a type of blood cancer that affects the bone marrow and results in an overproduction of immature WBCs. The genetic mutation that causes CML is the BCR-ABL fusion gene. Adolescents are rarely affected.
View Article and Find Full Text PDFA wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin's lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes are commonly deliberated as successful and restorative.
View Article and Find Full Text PDFArticle Synopsis
- - The COVID-19 pandemic significantly impacted pediatric cancer centers, with 75.9% of centers reporting difficulties in patient access and 72.4% seeing changes in patient flow due to the virus.
- - Over two-thirds of surveyed health care professionals were infected with COVID-19, leading to treatment guideline modifications in 62% of centers, while follow-up care was provided through various methods, including in-hospital and telemedicine.
- - Pediatric oncologists have mixed expectations about the long-term effects of COVID-19, with 76% anticipating increased telemedicine use, and over half believing that chemotherapy protocols may need adjustments if the pandemic continues.
Article Synopsis
- The study focused on the expression of toll-like receptor-9 (TLR9) in 40 newly diagnosed acute myeloid leukemia (AML) patients compared to 20 healthy controls.
- TLR9 expression was significantly lower in AML patients (median ≤ 1%) and was linked to poorer clinical outcomes, with lower survival rates for those with TLR9 expression ≤ 1%.
- The findings suggest that while TLR9 is present in AML cells, its low expression correlates with advanced disease and worse prognosis.
TET2 Single Nucleotide Polymorphism in Myeloid Neoplasms Among Egyptian Patients.
Indian J Hematol Blood Transfus
January 2020
Acute myelogenous leukemia (AML) is a heterogeneous disease characterized by myeloid progenitor cells uncontrolled proliferation gradually replacing normal hematopoiesis. To evaluate Ten Eleven Translocation 2 gene (TET2) single nucleotide polymorphism (SNP) (rs2454206, rs34402524, rs61744960) in AML, and chronic myeloid leukemia (CML) in relation to their disease prognostic criteria. The study included 136 subjects; 52 AML, 54 CML and 30 subjects as control group matched for age and sex.
View Article and Find Full Text PDFThe Prognostic Significance of TET2 Single Nucleotide Polymorphism in Egyptian Chronic Myeloid Leukemia.
Mediterr J Hematol Infect Dis
January 2020
Background: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm where pathogenesis is based on the oncoprotein termed BCR-ABL1.1 TET2 initiates DNA demethylation and is frequently mutated in hematological malignancies, including CML. The relation between TET2 acquisition and CML transformation and/or imatinib resistance is needed to be investigated.
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