Publications by authors named "En-jie Wang"

In this work, a series of highly porous sulfur-doped carbons are prepared through physical activation methods by using polythiophene as a precursor. The morphology, structure, and physicochemical properties are revealed by a variety of characterization methods, such as scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and nitrogen sorption measurement. Their porosity parameters and chemical compositions can be well-tuned by changing the activating agents (steam and carbon dioxide) and reaction temperature.

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Objective: To explore the effects of low-frequency electric stimulus (LFS) on hippocampal of α5 subunit of extrasynaptic GABAA receptor in kainic acid-induced epilepsy rats and explore the possible mechanism of LFS on hippocampus to treat epilepsy.

Methods: A total of 32 male Sprague-Dawley rats were divided randomly into 4 groups:epileptic, pseudo-surgery, LFS treatment and control. The expression of α5 subunit of extrasynaptic GABAA receptor and the association with the curative effects of LFS were evaluated by behavioristics, real-time fluorogenic quantitative polymerase chain reaction (PCR) and Western blot.

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Article Synopsis
  • The study investigates the expression of the α(5) subunit of extrasynaptic GABA(A) receptors in rats with induced insular epilepsy, using various control groups for comparison.
  • Results showed no significant difference in the number of hippocampal neurons across groups, but both mRNA levels and protein expression of the α(5) subunit were significantly lower in the kindled group compared to control and sham-operated groups at two different time points.
  • The findings suggest that decreased expression of the α(5) subunit in the hippocampus may be linked to the development and progression of insular epilepsy, indicating its potential role in this condition.
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Objective: To explore the expression of δ subunit-containing γ-aminobutyric acid(A) (GABA)(A) receptors in insular electrical kindled rats and analyze the significance of the findings.

Methods: A total of 48 male Sprague-Dawley rats were divided randomly into 3 groups: kindled, sham-operated and control. Kindled group: chronic insular electrical kindled models of rats established by electrical stimulation.

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