Publications by authors named "En-Ning Zhang"
Article Synopsis
- The study investigates the roles of the RIG-I receptor and its protein MAVS in osteoarthritis (OA) progression, focusing on genetic variations in a Chinese Han population.* -
- Four significant single nucleotide polymorphisms (SNPs) were analyzed, revealing that certain SNPs showed marginal and significant associations with OA, particularly in females.* -
- Overexpression of MAVS in chondrogenic cells decreased cell viability and increased apoptosis, suggesting that MAVS could be a new risk factor for OA by affecting chondrocyte growth and cartilage balance.*
In this study, gambogic acid (GA) and retinoic acid chlorochalcone (RACC) co-loaded glycol chitosan nanoparticle was successfully developed and studied for its therapeutic efficacy against osteosarcoma cancer cells. The GA/RACC loaded glycol chitosan nanoparticles (RGNP) was nanosized and exhibited a controlled release of drug in either pH 7.4 and pH 5.
View Article and Find Full Text PDFMicroRNA-153 expression and prognosis in non-small cell lung cancer.
Int J Clin Exp Pathol
June 2016
Article Synopsis
- * The study showed that lower miR-153 expression is associated with more advanced clinical stages, worse lymph node involvement, increased distant metastasis, and poorer differentiation in NSCLC patients.
- * Kaplan-Meier survival analysis suggested that patients with lower miR-153 levels have significantly worse overall survival rates, indicating that it could serve as an independent prognostic factor for NSCLC.
Objective: To evaluate the efficacy and toxicity of a biweekly DOF regimen consisting of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer.
Methods: The biweekly DOF regimen was administered in 37 advanced gastric cancer patients. Docetaxel, oxaliplatin and leucovorin were given intravenously at a dose of 35 mg/m2, 85 mg/m2 and 200 mg/m2 for 1 h, 2 h and 2 h on D1, respectively, and 5-Fu was administered as continuous intravenous infusion for 48 h at a dose of 1500 mg/m2 on D1 and D2.