Publications by authors named "En-Ni Chen"
To guide individualized intensity-modulated radiotherapy (IMRT), we developed and prospectively validated a multiview radiomics risk model for predicting radiation-induced hypothyroidism in patients with nasopharyngeal carcinoma. And simulated radiotherapy plans with same dose-volume-histogram (DVH) but different dose distributions were redesigned to explore the clinical application of the multiview radiomics risk model. The radiomics and dosiomics were built based on selected radiomics and dosiomics features from planning computed tomography and dose distribution, respectively.
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- * A total of 273 patients were treated, with those receiving both immunochemotherapy and radiotherapy showing significantly better progression-free survival (80.6% vs. 65.1%) and overall survival (98.3% vs. 89.5%) compared to those on immunochemotherapy alone.
- * The research highlights that the most benefit is seen in patients with oligometastases, lower levels of EBV DNA, and positive responses to immunochemotherapy, while also noting the presence of some treatment-related side effects.*
Background: The aim of this work was to determine whether patients with intermediate-risk head and neck squamous cell carcinoma (HNSCC) can benefit from postoperative chemoradiotherapy (POCRT).
Methods: Patients without extracapsular extension (ECE) or positive margins (PMs) who received POCRT or postoperative radiotherapy (PORT) at our center were retrospectively (December 2009 to October 2018) included for analysis, in particular, using a propensity score-matching method.
Results: After matching, 264 patients were enrolled, including 142 (41.
Objectives: We aimed to develop and validate radiologic scores from [F]FDG PET/CT and MRI to guide individualized induction chemotherapy (IC) for patients with T3N1M0 nasopharyngeal carcinoma (NPC).
Methods: A total of 542 T3N1M0 patients who underwent pretreatment [F]FDG PET/CT and MRI were enrolled in the training cohort. A total of 174 patients underwent biopsy of one or more cervical lymph nodes.
Purpose: We aimed to develop and prospectively validate a risk score model to guide individualized concurrent chemoradiotherapy (CCRT) for patients with stage II nasopharyngeal carcinoma (NPC) in intensity-modulated radiotherapy (IMRT) era.
Materials And Methods: In total, 1220 patients who received CCRT or IMRT alone were enrolled in this study, including a training cohort (n = 719), a validation cohort (n = 307), and a prospective test cohort (n = 194). Patients were stratified into different risk groups by a risk score model based on independent prognostic factors, which were developed in the training cohort.
Benefit of [18F]-FDG PET/CT for treatment-naïve nasopharyngeal carcinoma.
Eur J Nucl Med Mol Imaging
February 2022
Background: To test the advantages of positron emission tomography and computed tomography (PET/CT) for diagnosing lymph nodes and staging nasopharyngeal carcinoma and to investigate its benefits for survival and treatment decisions.
Methods: The performance of PET/CT and magnetic resonance imaging (MRI) in diagnosis was compared based on 460 biopsied lymph nodes. Using the propensity matching method, survival differences of T3N1M0 patients with (n = 1093) and without (n = 1377) PET/CT were compared in diverse manners.
Article Synopsis
- * The analysis included twelve trials and found that induction chemotherapy significantly improved both progression-free survival and overall survival, highlighting a 5-year absolute benefit of approximately 11.31% and 8.95%, respectively.
- * While the treatment showed considerable benefits in locoregional and distant control rates, there was also an increase in severe adverse events like leukopenia, thrombocytopenia, and fatigue among patients undergoing induction chemotherapy.
Autophagy plays a very important role in numerous physiological and pathological events. However, it still remains unclear whether Atg7-induced autophagy is involved in the regulation of neural crest cell production. In this study, we found the co-location of Atg7 and Pax7 neural crest cells in early chick embryo development.
View Article and Find Full Text PDFExcess Imidacloprid Exposure Causes the Heart Tube Malformation of Chick Embryos.
J Agric Food Chem
November 2016
As a neonicotinoid pesticide, imidacloprid is widely used to control sucking insects on agricultural planting and fleas on domestic animals. However, the extent to which imidacloprid exposure has an influence on cardiogensis in early embryogenesis is still poorly understood. In vertebrates, the heart is the first organ to be formed.
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