Publications by authors named "En-Jun Zhang"
Article Synopsis
- * The study reveals that a selective PI3Kδ inhibitor, TYM-3-98, can initiate ferroptosis (a type of non-apoptotic cell death) in KRAS-mutant CRC cells by disrupting key signaling pathways and enhancing lipid peroxidation.
- * In experiments with mouse models, TYM-3-98 effectively reduced tumor growth without causing significant liver or kidney toxicity, highlighting its potential as a novel therapeutic option for CRC.
Article Synopsis
- The researchers studied a protein called PI3Kδ, which is linked to cancers in white blood cells, and discovered that current medicines targeting it can have harmful side effects.
- They created a new drug called TYM-3-98 that specifically targets the PI3Kδ protein and works better than an older drug in fighting certain types of blood cancer.
- TYM-3-98 was shown to stop cancer cells from growing and helped shrink tumors in tests done on mice and human cancer cells.
