Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho.

Objective: Earlobe crease (ELC) has been considered as a skin sign of atherosclerosis, and its pathophysiological mechanism is still unclear. Our study aims to test the hypothesis that ELC patients with lower serum levels of the age-suppressing hormone Klotho, which is not only associated with premature aging but also with endothelial dysfunction, may be associated with atherosclerosis.

Methods: A total of 135 patients aged 40-68 years underwent coronary angiography.