Publications by authors named "Emylie-Ann Labbe"
Plasma and Myocardial miRNomes Similarities and Differences during Cardiac Remodelling and Reverse Remodelling in a Murine Model of Heart Failure with Preserved Ejection Fraction.
Sara-Ève Thibodeau Emylie-Ann Labbé Élisabeth Walsh-Wilkinson Audrey Morin-Grandmont Marie Arsenault
Biomolecules
July 2024
Article Synopsis
- Heart failure with preserved ejection fraction (HFpEF) is influenced by various risk factors that affect organs beyond the heart, and a study used a mouse model to explore the effects of metabolic-hypertensive stress and exercise on heart health.
- After a period of stress, the study found that stopping the stresses and introducing voluntary exercise led to significant cardiac improvements, especially in female mice who experienced loss of cardiac hypertrophy and remodeling.
- The research also revealed changes in plasma microRNA levels (miRs), which changed in response to stress; however, while plasma levels normalized after recovery, the heart tissue showed persistent abnormalities, indicating that circulatory markers alone may not provide a complete picture of heart health recovery.
After menopause, the incidence of cardiovascular disease rapidly rises in women. The disappearing protection provided by sex steroids is a consequence of the development of many risk factors. Preclinical studies are necessary to understand better the effects of ovarian hormones loss cardiac aging.
View Article and Find Full Text PDFCardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle.
Mohamed Lamine Aidara Élisabeth Walsh-Wilkinson Sara-Ève Thibodeau Emylie-Ann Labbé Audrey Morin-Grandmont
Am J Physiol Heart Circ Physiol
April 2024
Multiple factors cause heart failure with preserved ejection fraction (HFpEF) and involve various systems. HFpEF prevalence is rapidly rising, and its prognosis remains poor after the first hospitalization. Adopting a more active lifestyle has been shown to provide beneficial clinical outcomes for patients with HFpEF.
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