[Development and optimization of diagnostically informative boichemical and coagulative correlators in various atherosclerotic lesions of carotid arteries].

Diagnostically informative biochemical and coagulative correlators in various atherosclerotic lesions of carotid arteries are developed. It has been established positive correlation of the degree of stenosis and intima-media thickness of carotid arteries with the following biochemical parameters: total cholesterol, LDL cholesterol, Apo-B, Lp(a), triglycerides, hs-C-reactive protein(CRP), interleukines (IL-1ß and IL-6), fibrinogen, D-dimers. Negative correlation was stated with respect to HDL cholesterol, Apo-A-1, protein C.

[Pecularities of atherosclerosis developed after chlamidial infection and behaviour of some hematological and biochemical parameters].

The aim of our studies was to create diagnostically informative criteria of hematologic and biochemical analyses and their combinations as well as to establish relation between Chlamidia Pneumoniae A and atherosclerosis. This is to be done for the purpose of establishing the entire pathogenesis carotid and coronary atherosclerosis and inflammation. The investigation of Chlamidia Pneumoniae infection in proved to be a possible risk factor for the carotid atherosclerosis developed in adults that makes the course of atherosclerosis heavier.

[Correlation of some biochemical and coagulological parameters in carotid atherosclerosis].

It has been established positive correlation of the degree of stenosis and intima-media thickness of carotid arteries with the following biochemical parameters: total cholesterol, LDL cholesterol, Apo-B, Lp(a), triglycerides, hs-C-reactive protein(CRP), interleukines (IL-1beta and IL-6), fibrinogen, D-dimers. Negative correlation was stated with respect to HDL cholesterol, Apo-A-1, protein C. Relation between the parameters of the blood lipid spectre, proteins and mediators of inflammation as well as those of hemostasis enables us to approach pathophysiological mechanisms of carotid atherosclerosis, define the processes of inflammation and atherosclerosis.

[The effect of chemotherapy treatment on hemostasis of patients with lung cancer].

Chemotherapy is known to raise the risk of developing thrombotic complications. The aim of our work is to study the system of hemostasis in patients with the lung cancer under chemotherapy treatment. 61 patients were examined (40 men, 21 women) between the ages of 32 and 75 years (the principal group).

[Modern view on biochemistry of atherosclerosis].

The article summarizes the literature data on clinical chemistry of pathogenesis of atherosclerosis. According to the up-to-date view, atherogenic are considered the products of chemical modification of LDL, rather than LDL themselves. The modification is created by means of the free radicals or reactive oxidised nitrogen species (RONS).