Design, synthesis, biological evaluation, and molecular modeling studies of some quinazolin-4(3)-one-benzenesulfonamide hybrids as potential α-glucosidase inhibitors.

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia, posing serious health risks and becoming increasingly prevalent. Prolonged hyperglycemia can lead to complications such as nephropathy, neuropathy, retinopathy, cardiovascular damage, and blindness. Controlling hyperglycemia through α-glucosidase inhibitors, which slow down carbohydrate breakdown, is an effective treatment strategy.