Publications by authors named "Emre Hari"
Despite converging evidence of hierarchical organization in the cerebral cortex, with sensory-motor and association regions at opposite ends, the mechanism of such hierarchical interactions remains elusive. This organization was primarily investigated regarding the spatiotemporal dynamics of intrinsic connectivity networks (ICNs). However, more effort is needed to investigate network dynamics in the frequency domain.
View Article and Find Full Text PDFObjective: Memory processes known to be impaired in Alzheimer's disease (AD) are maintained by a large-scale neurocognitive network with subcortical components, including the thalamus. Therefore, we aimed to examine the volumetric and functional changes of the thalamic nuclei at different scales across AD stages.
Methods: MRI data of patients diagnosed with 20 AD dementia (ADD), 30 amnestic mild cognitive impairment (MCI), and 30 subjective cognitive impairment (SCI) were used.
The spread pattern of progressive degeneration seen in Alzheimer's disease (AD) to small-scale medial temporal lobe subregions is critical for early diagnosis. In this context, it was aimed to examine the morphometric changes of the hippocampal subfields, amygdala nuclei, entorhinal cortex (ERC), and parahippocampal cortex (PHC) using MRI. MRI data of patients diagnosed with 20 Alzheimer's disease dementia (ADD), 30 amnestic mild cognitive impairment (aMCI), and 30 subjective cognitive impairment (SCI) without demographic differences were used.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how Alzheimer's disease affects the Papez circuit, which is crucial for memory, by analyzing functional and structural connectivity in patients at different stages of cognitive impairment.
- - Researchers evaluated MRI data from groups with Alzheimer's dementia, mild cognitive impairment, and subjective cognitive issues, finding early connectivity changes between specific brain regions associated with memory.
- - Key results showed that early disruptions in connectivity and later structural changes in certain pathways can predict memory performance in individuals, highlighting the Papez circuit's significance in understanding Alzheimer's disease progression.
Article Synopsis
- The study explores how neurodegeneration in Alzheimer's disease progresses from the transentorhinal cortex through the hippocampus, specifically analyzing volumetric changes in hippocampal subfields among different stages of the Alzheimer's disease continuum (ADC).
- MRI data was collected from three groups: patients with Alzheimer's disease dementia (ADD), those with amnestic mild cognitive impairment (MCI), and individuals with subjective cognitive impairment (SCI), using software to obtain and compare volumetric values of hippocampal subfields (CA1, CA3, SUB, DG).
- Significant volume reductions were found in the CA1, SUB, and DG subfields in the ADD group when compared to the MCI and SCI groups, while no notable changes were observed
Objective: Juvenile myoclonic epilepsy (JME) is typified by the occurrence of myoclonic seizures after awakening, though another common trait is myoclonic seizures triggered by photic stimulation. We aimed to investigate the functional connectivity (FC) of nuclei in the ascending reticular activating system (ARAS), thalamus and visual cortex in JME with and without photosensitivity.
Methods: We examined 29 patients with JME (16 photosensitive (PS), 13 non- photosensitive-(NPS)) and 28 healthy controls (HCs) using resting-state functional magnetic resonance imaging (rs-fMRI).