Publications by authors named "Emoto A"

Article Synopsis
  • Apremilast has been shown to be safe and effective for treating psoriatic diseases, including plaque psoriasis (PsO) and psoriatic arthritis (PsA), in Japanese patients based on post-marketing surveillance conducted after its approval in 2016.
  • The study, which involved over 1,000 patients observed for 12 months, reported that adverse reactions (ARs) occurred in about 29.4% of patients, with gastrointestinal issues being the most common; serious ARs were rare and no serious infections or fatalities were reported.
  • Effectiveness results indicated substantial improvement in PsO patients, with 90.9% achieving global improvement after 6 months and 93.8% after 12
View Article and Find Full Text PDF

Compound lens systems with mechanical actuators are used to focus objects at near to far distances. The focal length of ultrasound varifocal liquid crystal (LC) lenses can be controlled by modulating the refractive index spatial distribution of the medium through the acoustic radiation force, resulting in thin and fast-response varifocal lenses. The frequency characteristics of such a lens are evaluated in this paper, and several axisymmetric resonant vibration modes over 20 kHz are observed.

View Article and Find Full Text PDF

A kind of citrus fruit with special flavor, Citrus sudachi harvested in Japan, are exported to various countries. However, the Citrus sudachi needs to be sterilized using aqueous solution of sodium hypochlorite because there is a possibility of the adhesion of citrus bacterial canker (CBC) which is not found in Europe. Due to the sterilization with time-consuming work, a more effective decontamination technique is required.

View Article and Find Full Text PDF

What Is Known And Objective: The use of hypnotics, especially benzodiazepines (BZs), increases the risk of falls. Regarding the association of orexin receptor antagonists with fall risk, consistent results have not been obtained for suvorexant, and studies of lemborexant have not been reported. Therefore, this study investigated whether orexin receptor antagonists, including lemborexant, increase the risk of falls.

View Article and Find Full Text PDF

New technologies for adaptive optics are becoming increasingly important for miniature devices such as cell-phone cameras. In particular, motion-free autofocusing and optical image stabilization require sophisticated approaches for alternative lens architectures, materials, and processing to replace multiple solid elements. We discuss a new method, to the best of our knowledge, that provides image stabilization via an annular piezoelectric ceramic that uses ultrasound to drive a liquid crystal layer sandwiched between two circular glass substrates.

View Article and Find Full Text PDF

In this paper, we propose a novel approach to fabricate fluidic chips. The method utilizes molecular cross-diffusion, induced by photopolymerization under ultraviolet (UV) irradiation in a channel pattern, to form the channel structures. During channel structure formation, the photopolymer layer still contains many uncured molecules.

View Article and Find Full Text PDF

Before surgery and other invasive treatments, decisions must be made on whether to discontinue drugs and provide appropriate drug holidays especially for antithrombotic drugs, and this is made difficult by the large number of available drugs and associated guidelines. We have therefore developed an online application for perioperative drug discontinuation and resumption management, named Saga Application for Management of Drug Holidays in PeriOperative Periods (SAMPOP).Multidisciplinary medical staff at Saga University Hospital (SUH) worked together to build an evidence-based Perioperative Drug Discontinuation Management Database (PDDMD) and developed the user-friendly SAMPOP online application via preliminary verification at SUH.

View Article and Find Full Text PDF

A method to estimate orientation direction of liquid crystal molecules three-dimensionally under ultrasound excitation was proposed and the relationship between the ultrasound vibration and the molecular orientation was discussed. Our group have reported a technique to control orientation direction of liquid crystal molecules using ultrasound vibration which could be applied to an optical variable-focus liquid crystal lens. The lens consisted of a liquid crystal layer sandwiched by two glass circular discs and a piezoelectric ring.

View Article and Find Full Text PDF

In our previous study, we developed an array of unique porous structures (an array of barnacle-like porous structures) to apply to biosensing chips. The porous structure was formed by an internal swelling phenomenon of a polystyrene colloidal particle monolayer, which was surrounded by a poly(vinyl alcohol) layer, for the duration of the monolayer's immersion in a toluene bath. Barnacle-like porous structures were formed when polystyrene particles that had rapidly swelled broke the outer layer around the top of the particles.

View Article and Find Full Text PDF

As a potential means of measuring birefringence distribution, we analyzed the interference fringes based on three circularly polarized beams: a right-handed signal beam, a left-handed reference beam, and a right-handed reference beam. All beams were crossed at the same angle on the interfering plane, creating a two-dimensional interference fringe with three grating vectors. We proposed that by analyzing the interference fringes, we can measure the anisotropic phase shift in the signal beam.

View Article and Find Full Text PDF

BACKGROUND Psoriasis is known as the most frequent disease treated by long-term topical steroids. It is also known that patients with thick, chronic plaques require the highest potency topical steroids. However, the treatment is limited to up to four weeks due to risk of systemic absorption.

View Article and Find Full Text PDF

Background: Poor adherence to ABL tyrosine kinase inhibitors (ABL TKIs) is associated with reduced treatment efficacy and increased healthcare costs. To examine the hazards associated with poor adherence, we implemented failure mode and effects analysis (FMEA).

Methods: We surveyed 54 chronic myeloid leukemia (CML) patients treated at Saga University Hospital from October 2012 to May 2014.

View Article and Find Full Text PDF

Pores with an outer shell (POS) are fabricated on the submicrometer scale using modified poly(vinyl alcohol) (PVA). An aqueous solution is mixed with cationic PVA and a water-based colloidal suspension of polystyrene (PS) spheres of submicrometer diameter. The mixture is then spin-coated onto a substrate.

View Article and Find Full Text PDF

For Fourier transform holography, an effective random phase distribution with randomly displaced phase segments is proposed for obtaining a smooth finite optical intensity distribution in the Fourier transform plane. Since unitary phase segments are randomly distributed in-plane, the blanks give various spatial frequency components to an image, and thus smooth the spectrum. Moreover, by randomly changing the phase segment size, spike generation from the unitary phase segment size in the spectrum can be reduced significantly.

View Article and Find Full Text PDF

The diffraction properties of reflective anisotropic gratings, which can be recorded in photoanisotropic media with uniaxial birefringence by three-dimensional vector holography, were characterized through the use of coupled-wave analysis (CWA). By investigating the perturbation of the dielectric tensor, we demonstrated that the gratings with sinusoidal distribution of the azimuthal angle of the optic axis diffract polarized light in which the ordinary and extraordinary components are converted for incident light. The polarization conversion was consistent with that calculated by a numerical method.

View Article and Find Full Text PDF

The diffraction properties of thick vector holograms were analyzed with the use of a simple coupled-wave theory. Two eigenpolarizations in the holograms were determined based on the dielectric perturbation, and diffraction efficiencies for the polarizations were calculated by applying the Kogelnik method. The results were compared with those simulated by the finite-difference time-domain method.

View Article and Find Full Text PDF
Article Synopsis
  • A microperiodic structure known as holographic polymer dispersed liquid crystals (LCs) is created using a photo-induced phase separation technique, involving different LC composites.
  • The study examines how temperature and polarization affect the diffraction properties of these LC composite gratings.
  • The changes in refractive index due to the LCs' transition from a nematic to isotropic state at higher temperatures facilitate holographic image reconstruction.
View Article and Find Full Text PDF

We theoretically investigate optical birefringence originating from subwavelength structures in intrinsic birefringent media. Assuming alternating layers of isotropic and anisotropic materials, the propagation of optical waves is simulated on the basis of the finite difference time domain method. Optical polarization changes throughout the structure reveal the birefringence of the layered structure as a whole.

View Article and Find Full Text PDF

Diffractive optical devices using low-molar-mass liquid crystals are of great important for realizing numerical optical functions such as optical memory and information systems. In the present study the liquid crystalline gratings have been fabricated using a pair of photo-alignment substrates, and effects of the phase shift between the two photo-alignment substrates on the diffraction properties have been investigated. The liquid crystalline grating has been constructed with variable polarization dependence that can be controlled by the phase shift between the two photo-alignment substrates and twisted angles of the nematic directors.

View Article and Find Full Text PDF

The patient was a 74-year-old woman with Parkinson's disease who had a past history of total hysterectomy for uterine myoma. She was admitted for a femoral neck fracture and treated conservatively. From the third day of the illness, the patient experienced increased urinary frequency and constant urge to urinate.

View Article and Find Full Text PDF

Aims: The pelvic floor muscle (PFM) training is effective in alleviating the symptoms of urinary incontinence, but there are very few reports available on its long-term effectiveness. Therefore, 8-year follow-up data have been prospectively analyzed.

Materials And Methods: Originally 123 women with stress or mixed urinary incontinence participated in an 8-week intensive PFM training program.

View Article and Find Full Text PDF

We present a rare case of transitional cell carcinoma of the navicular fossa in an elderly man. We detected the expression of human papillomavirus type 16 specific DNA sequence in the tumor using polymerase chain reaction. Human papillomavirus dissemination into the urethra by urethral instrumentation might cause urethral tumors, such as squamous cell carcinoma or condyloma acuminatum, and also transitional cell carcinoma as seen in the present case.

View Article and Find Full Text PDF

Highly efficient and functionalized polarization gratings have been recorded in azobenzene-containing mesogenic composites with twisted nematic cell configurations. The polarization gratings formed in azobenzene-containing mesogenic composites show a high diffraction efficiency of more than 45% and convert the polarization state of light at the same time. The polarization direction of the diffracted laser beams can be controlled by the twisted angle of the nematic cell.

View Article and Find Full Text PDF

A 31-year-old, previously normotensive healthy man developed right flank pain and was admitted to a medical service. Right renal infarction was suspected by enhanced abdominal computed tomography (CT) and arteriography. Fourteen days after the onset, he was transferred to the Oita University Hospital, Oita, Japan.

View Article and Find Full Text PDF

Escherichia coli DnaA protein initiates chromosomal replication and is an important regulatory target during the replication cycle. In this study, a suppressor mutation isolated by transposon mutagenesis was found to allow growth of the temperature-sensitive dnaA508 and dnaA167 mutants at 40 degrees C. The suppressor consists of a transposon insertion in a previously annotated ORF, here termed hspQ, a novel heat shock gene whose promoter is recognized by the major heat shock sigma factor sigma32.

View Article and Find Full Text PDF