A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis.

Bactofilins have emerged as a widespread family of cytoskeletal proteins with important roles in bacterial morphogenesis, but their precise mode of action is still incompletely understood. In this study, we identify the bactofilin cytoskeleton as a key regulator of cell growth in the stalked budding alphaproteobacterium . We show that, in this species, bactofilin polymers localize dynamically to the stalk base and the bud neck, with their absence leading to unconstrained growth of the stalk and bud compartments, indicating a central role in the spatial regulation of cell wall biosynthesis.

Quantum Interference and Nonequilibrium Josephson Currents in Molecular Andreev Interferometers.

We study the quantum interference (QI) effects in three-terminal Andreev interferometers based on polyaromatic hydrocarbons (PAHs) under non-equilibrium conditions. The Andreev interferometer consists of a PAH coupled to two superconducting and one normal conducting terminals. We calculate the current measured in the normal lead as well as the current between the superconducting terminals under non-equilibrium conditions.

Hemoglobin Levels and Serum C-Reactive Protein in Patients With Moderate to Severe Hidradenitis Suppurativa.

Introduction: Anemia of chronic inflammation is associated with many inflammatory diseases. Little is known about anemia in hidradenitis suppurativa (HS). This study aimed to review the levels of hemoglobin (Hb) and investigate its relationship with serum C-reactive protein (CRP) and disease severity in HS patients.

Dynamics of the peptidoglycan biosynthetic machinery in the stalked budding bacterium Hyphomonas neptunium.

Most commonly studied bacteria grow symmetrically and divide by binary fission, generating two siblings of equal morphology. An exception to this rule are budding bacteria, in which new offspring emerges de novo from a morphologically invariant mother cell. Although this mode of proliferation is widespread in diverse bacterial lineages, the underlying mechanisms are still incompletely understood.

First principles based proximity effect of superconductor-normal metal heterostructures.

In this paper we study the proximity effect in superconductor-normal metal heterostructures based on first principles calculations with treating the pairing potential as an adjustable parameter. The superconducting order parameter (anomalous density) is obtained from the Green-function by solving the Kohn-Sham-Bogoliubov-de Gennes equations with the Screened Korringa-Kohn-Rostoker method. The results are interpreted for an Au/Nb(0 0 1) system.

Transfer matrix approach for the Kerr and Faraday rotation in layered nanostructures.

To study the optical rotation of the polarization of light incident on multilayer systems consisting of atomically thin conductors and dielectric multilayers we present a general method based on transfer matrices. The transfer matrix of the atomically thin conducting layer is obtained using the Maxwell equations. We derive expressions for the Kerr (Faraday) rotation angle and for the ellipticity of the reflected (transmitted) light as a function of the incident angle and polarization of the light.

Human albumin eye drops as a therapeutic option for the management of keratoconjunctivitis sicca secondary to chronic graft-versus-host disease after stem-cell allografting.

Background: Keratoconjunctivitis sicca from chronic graft-versus-host disease (cgvhd) after allogeneic stem cell transplantation is common, leading to severe corneal damage and blindness if not treated. We retrospectively examined the efficacy and safety of pooled human albumin eye drops (haeds) for symptom relief in 40 stem-cell transplantation patients after other alternatives had failed.

Methods: The Common Terminology Criteria for Adverse Events (version 4.

Molecular toolbox for genetic manipulation of the stalked budding bacterium Hyphomonas neptunium.

The alphaproteobacterium Hyphomonas neptunium proliferates by a unique budding mechanism in which daughter cells emerge from the end of a stalk-like extension emanating from the mother cell body. Studies of this species so far have been hampered by the lack of a genetic system and of molecular tools allowing the regulated expression of target genes. Based on microarray analyses, this work identifies two H.

Human brain distinctiveness based on EEG spectral coherence connectivity.

The use of EEG biometrics, for the purpose of automatic people recognition, has received increasing attention in the recent years. Most of the current analyses rely on the extraction of features characterizing the activity of single brain regions, like power spectrum estimation, thus neglecting possible temporal dependencies between the generated EEG signals. However, important physiological information can be extracted from the way different brain regions are functionally coupled.

Advanced simulation of conductance histograms validated through channel-sensitive experiments on indium nanojunctions.

We demonstrate a self-contained methodology for predicting conductance histograms of atomic and molecular junctions. Fast classical molecular-dynamics simulations are combined with accurate density functional theory calculations predicting both quantum transport properties and molecular-dynamics force field parameters. The methodology is confronted with experiments on atomic-sized indium nanojunctions.

Spore formation in Myxococcus xanthus is tied to cytoskeleton functions and polysaccharide spore coat deposition.

Myxococcus xanthus is a Gram-negative bacterium that differentiates into environmentally resistant spores. Spore differentiation involves septation-independent remodelling of the rod-shaped vegetative cell into a spherical spore and deposition of a thick and compact spore coat outside of the outer membrane. Our analyses suggest that spore coat polysaccharides are exported to the cell surface by the Exo outer membrane polysaccharide export/polysaccharide co-polymerase 2a (OPX/PCP-2a) machinery.

Applications of medical intelligence in remote monitoring.

Prevention and rehabilitation efficiency can greatly benefit from the application of intelligent, 24 hour tele-diagnostics and tele-care information systems. Tele-monitoring also supports a new level of medical supervision over the patient's lifestyle. In this paper we briefly present the architecture and development phase results of the Alpha remote monitoring system.

Caustics due to a negative refractive index in circular graphene p-n junctions.

We show that the wave functions form caustics in circular graphene p-n junctions which in the framework of geometrical optics can be interpreted with a negative refractive index.

Proceedings of a Consensus Conference: pathogen inactivation-making decisions about new technologies.

Significant progress has been made in reducing the risk of pathogen transmission to transfusion recipients. Nonetheless, there remains a continuing risk of transmission of viruses, bacteria, protozoa, and prions to recipients. These include many of the viruses for which specific screening tests exist as well as pathogens for which testing is currently not being done, including various species of bacteria, babesiosis, variant Creutzfeld-Jacob disease, hepatitis A virus, human herpes virus 8, chikungunya virus, Chagas disease, and malaria.

Role of the trigonal warping on the minimal conductivity of bilayer graphene.

Using a reformulated Kubo formula we calculate the zero-energy minimal conductivity of bilayer graphene taking into account the small but finite trigonal warping. We find that the conductivity is independent of the strength of the trigonal warping and it is 3 times as large as that without trigonal warping and 6 times larger than that in single layer graphene. Although the trigonal warping of the dispersion relation around the valleys in the Brillouin zone is effective only for low-energy excitations, our result shows that its role cannot be neglected in the zero-energy minimal conductivity.

The ABO blood group system and Plasmodium falciparum malaria.

In the century since the discovery of the ABO blood groups, numerous associations between ABO groups and disease have been noted. However, the selection pressures defining the ABO distributions remain uncertain. We review published information on Plasmodium falciparum infection and ABO blood groups.

Light-chain removal by plasmapheresis in myeloma-associated renal failure.

Background: Although plasmapheresis has been recommended to reverse nephrotoxic elevations of serum free light chains (sFLCs), there are scant published data on removal of sFLC measured with modern assays.

Study Design And Methods: sFLC levels were recorded in two patients with myeloma-associated renal failure receiving multiple plasmapheresis procedures.

Results: In one patient, presenting with acute renal failure 8 months after diagnosis of kappa-LC myeloma, 16 plasmapheresis procedures neither reduced sFLC levels (percent removal ranging from -70% to +40%) nor improved renal function.

Do infections provoke exacerbations and relapses of thrombotic thrombocytopenic purpura?

Several case reports have suggested an association between infections and thrombotic thrombocytopenic purpura (TTP). In Case 1, a 37-year-old female presented with TTP 6 times over 7 years, requiring 242 therapeutic plasma exchanges (TPE), for a per-course range of 4-57 TPE (median 48), and treatment durations of 4-241 days (median 71 days), largely on account of multiple exacerbations (range 0-3, median 3). Twelve of 17 (71%) of her presentations or exacerbations were associated with suspected infections, with confirmation in 9 episodes.

Quantum-classical correspondence in the wave functions of andreev billiards.

We present a classical and quantum mechanical study of an Andreev billiard with a chaotic normal dot. We demonstrate that the nonexact velocity reversal and the diffraction at the edges of the normal-superconductor contact render the classical dynamics of these systems mixed indicating the limitations of a widely used retracing approximation. We point out the close relation between the mixed classical phase space and the properties of the quantum states of Andreev billiards, including periodic orbit scarring and localization of the wave function onto other classical phase space objects such as intermittent regions and quantized tori.

Tunable Lyapunov exponent in inverse magnetic billiards.

The stability properties of the classical trajectories of charged particles are investigated in a two-dimensional inverse magnetic domain, where the magnetic field is zero inside the domain and constant outside. As an example, we present detailed analysis for stadium-shaped domain. In the case of infinite magnetic field, the dynamics of the system is the same as in the Bunimovich billiard, i.

Proximity-induced subgaps in andreev billiards.

We examine the density of states of an Andreev billiard and show that any billiard with a finite upper cutoff in the path length distribution P(s) will possess an energy gap on the scale of the Thouless energy. An exact quantum mechanical calculation for different Andreev billiards gives good agreement with the semiclassical predictions when the energy dependent phase shift for Andreev reflections is properly taken into account. Based on this new semiclassical Bohr-Sommerfeld approximation of the density of states, we derive a simple formula for the energy gap.

International Organization for Migration: experience on the need for medical evacuation of refugees during the Kosovo crisis in 1999.

The International Organization for Migration (IOM) developed and implemented a three-month project entitled Priority Medical Screening of Kosovar Refugees in Macedonia, within the Humanitarian Evacuation Program (HEP) for Kosovar refugees from FR Yugoslavia, which was adopted in May 1999. The project was based on an agreement with the office of United Nations High Commission for Refugees (UNHCR) and comprised the entry of registration data of refugees with medical condition (Priority Medical Database), and classification (Priority Medical Screening) and medical evacuation of refugees (Priority Medical Evacuation) in Macedonia. To realize the Priority Medical Screening project plan, IOM developed and set up a Medical Database linked to IOM/UNHCR HEP database, recruited and trained a four-member data entry team, worked out and set up a referral system for medical cases from the refugee camps, and established and staffed medical contact office for refugees in Skopje and Tetovo.

Gender-differences in myocardial adaptation to afterload in normotensive and hypertensive rats.

Echocardiographic studies suggest that women appear to exhibit a greater degree of myocardial hypertrophy in response to increased afterload than men. Therefore, gender differences and the role of estrogen and testosterone in the development of myocardial hypertrophy were studied in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Male and female rats were either surgically neutered or underwent a sham operation at 21 days of age.