[Prescription of acetaminophen in five French hospitals: What are the practices?].

Aim: Acetaminophen is widely used in hospital settings and often considered as nontoxic. We conducted a multicentric study in order to evaluate its proper use.

Method: Prescriptions from five general hospitals were analyzed, according to dose adjustments required in renal or liver failure, weight or chronic alcoholism, determined using a literature review.

[Proton Pump Inhibitor and High-dose Methotrexate: Two Cases Reports].

Methotrexate (MTX) is a cytotoxic agent prescribed at high dose in treatment of malignancy. Association of MTX to proton pump inhibitor (PPI) is not recommended if doses are more than 20 mg per weeks and only to take into account for smaller doses. Review relate some cases of delayed elimination of methotrexate in patients taking PPI, which increase risk of toxic event.

[Pharmaceutical analysis and validation of hospital prescriptions, a 5-year study].

Background: Analysis and validation of hospital prescriptions by the pharmacy department, although mandatory since 1991, appears relatively uncommon. Little is known of the nature and frequency of the actions taken by clinical pharmacists during this process.

Objective: To describe the nature and frequency of pharmaceutical interventions in a large university hospital.