Publications by authors named "Emmanuelle Netzer"
Article Synopsis
- The ANRS|MIE CoviCompareP study investigated COVID-19 breakthrough infections among vaccinated adults during the Omicron variant's circulation, focusing on those vaccinated with the Pfizer-BioNTech vaccine.
- The study involved healthy adults divided into groups based on previous SARS-CoV-2 infection status and monitored their neutralizing antibodies after vaccination and boosters.
- Results showed that 31% of participants experienced breakthrough infections, with lower infection risks linked to older age, more booster doses, and higher neutralizing antibody levels, especially in those with prior infections.
Objectives: Presence of baseline hepatitis C virus (HCV) resistance-associated substitutions (RASs) can impair treatment outcome of direct-acting antivirals. We investigated the prevalence of pre-treatment HCV resistance among recently HCV-infected men who have sex with men (MSM) with high risk behaviours, either human immunodeficiency virus (HIV) co-infected or at high risk of HIV acquisition and under pre-exposure prophylaxis (PrEP).
Methods: NS5A and NS3 fragments were deep sequenced on pre-treatment samples of 72 subjects using Illumina MiSeq paired-end sequencing technology.
We assessed the coverage of sex acts by event-driven pre-exposure prophylaxis (ED-PrEP) over a 2-month period in 54 participants in the open label phase of the ANRS Ipergay trial. Participants received an electronic monitoring system device to record bottle openings. Self-questionnaires collected daily information on PrEP intake and sexual behavior.
View Article and Find Full Text PDFIntroduction: Mixed hepatitis C virus (HCV) genotype (GT) infections are clinically important as different genotypes have varied sensitivities to direct-acting antivirals (DAAs). A high prevalence of mixed GT infections was observed in individuals who inject drugs and had multiple HCV exposures. The prevalence of mixed HCV GT infections in men who have sex with men (MSM) and high-risk behaviors was investigated by ultra-deep sequencing (UDS).
View Article and Find Full Text PDFObjective: Several studies reported hepatitis C virus (HCV) transmission networks among men having sex with men (MSM) in Europe and the spread of HCV strains from HIV-HCV coinfected toward HCV monoinfected MSM. We aimed to investigate HCV transmission dynamics among HIV-positive and HIV-negative MSM by ultradeep sequencing (UDS).
Design And Methods: NS5B fragment (388 bp) was sequenced from virus of 50 HIV-positive and 18 HIV-negative patients diagnosed with recent HCV infection.
Article Synopsis
- Late onset neonatal sepsis (LOS) poses high mortality risks, and the study aimed to assess new clinical criteria for better management and antibiotic effectiveness in Europe.
- The study involved 113 infants, with most cases being culture-proven, revealing a 61% success rate for the expert panel's diagnostic criteria.
- Findings highlighted significant variability in current antibiotic treatments, with 8% mortality and 45% failure rates, emphasizing the need for standardized, evidence-based guidelines.
Objective: Interleukin (IL)-2 therapy leads to significant CD4 cell increases in HIV-infected patients. Since phase III trials are ongoing, studies supporting the long-term feasibility of this strategy are needed.
Methods: We studied the long-term outcomes of 131 patients treated with IL-2 in two studies initiated either before (ANRS 048) or following (ANRS 079) the advent of HAART.