Publications by authors named "Emmanuelle Lefevre"

Juvenile bone growth is well described (physiological and anatomical) but there are still lacks of knowledge on intrinsic material properties. Our group has already published, on different samples, several studies on the assessment of intrinsic material properties of juvenile bone compared to material properties of adult bone. The purpose of this study was finally to combine different experimental modalities available (ultrasonic measurement, micro-Computed Tomography analysis, mechanical compression tests and biochemical measurements) applied on small cubic bone samples in order to gain insight into the multiparametric evaluation of bone quality.

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Article Synopsis
  • Human cortical bone is made of two tissue types: osteonal and interstitial, but differences in their mechanical properties during growth are still unclear.
  • This study analyzed bone samples from both juvenile (ages 4-18) and adult (ages 50-95) donors using various techniques to assess their mechanical properties and composition.
  • Results indicated that juvenile bone has intrinsic properties that are not necessarily inferior to adult bone and that mechanical properties vary between juvenile and adult bones, suggesting distinct considerations in juvenile bone research.
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Cortical porosity is a major determinant of bone strength. Haversian and Volkmann׳s canals are׳seen' as pores in 2D cross-section but fashion a dynamic network of interconnected channels in 3D, a quantifiable footprint of intracortical remodeling. Given the changes in bone remodeling across life, we hypothesized that the 3D microarchitecture of the cortical pore network influences its stiffness during growth and ageing.

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When assessing ultrasonic measurements of material parameters, the signal processing is an important part of the inverse problem. Measurements of thickness, ultrasonic wave velocity and mass density are required for such assessments. This study investigates the feasibility and the robustness of a wavelet-based processing (WBP) method based on a Jaffard-Meyer algorithm for calculating these parameters simultaneously and independently, using one single ultrasonic signal in the reflection mode.

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Child cortical bone tissue is rarely studied because of the difficulty of obtaining samples. Yet the preparation and ultrasonic characterization of the small samples available, while challenging, is one of the most promising ways of obtaining information on the mechanical behavior of non-pathological children׳s bone. We investigated children׳s cortical bone obtained from chirurgical waste.

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