Publications by authors named "Emmanuela N Bonglack"
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that typically causes asymptomatic infection but can promote B lymphoid tumors in the immune suppressed. In vitro, EBV infection of primary B cells stimulates glycolysis during immortalization into lymphoblastoid cell lines (LCLs). Lactate export during glycolysis is crucial for continued proliferation of many cancer cells-part of a phenomenon known as the "Warburg effect"- and is mediated by monocarboxylate transporters (MCTs).
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- Lymphoblastoid cell lines (LCLs) are created from B cells infected with Epstein-Barr virus (EBV) and are important for research in areas like viral oncology and immunology.
- This study used single-cell RNA sequencing to analyze five LCLs, revealing significant differences in gene expression related to immune responses and viral activity.
- The research also developed a simulation model to show how the initial variation in B cells and random factors during culture can lead to diverse outcomes in seemingly identical cell populations.